Mechanisms and Control of Widespread Spinally Mediated Inhibition
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De Boef, Adam
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Abstract
Proprioceptive feedback plays a crucial role in motor control. Proprioceptive feedback allows muscles to interact with one another, through excitatory and inhibitory pathways. Historically, there is a debate about the extent to which each proprioceptor contributes to intermuscular interactions. Previous work from our lab maps the inhibitory connections of proprioceptive feedback between muscles in the feline hindlimb, and suggests they are mediated by the force sensitive (Ib) pathways alone. Synaptic connections within the spinal cord suggest the connections should be mediated by a combined length and force contribution.
Previous work from our lab demonstrates that animals with incomplete spinal cord injuries (iSCI) have disrupted inhibitory network between muscles. Utilizing three different iSCI models, the proprioceptive sources of intermuscular inhibition, and the descending control of the corresponding interneuronal network, were investigated using mechanographic methods. This project provides evidence that the group II afferents contribute to intermuscular inhibition and become over expressed after iSCI. This project also provides evidence that the medullary reticulospinal pathway regulates the structure of inhibition across the feline hindlimb.
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2023-04-27
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Dissertation