MRI methods for predicting response to cardiac resynchronization therapy

dc.contributor.advisor Oshinski, John N.
dc.contributor.author Suever, Jonathan D.
dc.contributor.committeeMember Brummer, Marijn E.
dc.contributor.committeeMember Lloyd, Michael S.
dc.contributor.committeeMember Sechopoulos, Ioannis
dc.contributor.committeeMember Tang, Xiangyang
dc.contributor.committeeMember Yezzi, Anthony J.
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2014-01-13T16:19:42Z
dc.date.available 2014-01-13T16:19:42Z
dc.date.created 2013-12
dc.date.issued 2013-08-02
dc.date.submitted December 2013
dc.date.updated 2014-01-13T16:19:42Z
dc.description.abstract Cardiac Resynchronization Therapy (CRT) is a treatment option for heart failure patients with ventricular dyssynchrony. CRT corrects for dyssynchrony by electrically stimulating the septal and lateral walls of the left ventricle (LV), forcing synchronous con- traction and improving cardiac output. Current selection criteria for CRT rely upon the QRS duration, measured from a surface electrocardiogram, as a marker of electrical dyssynchrony. Unfortunately, 30-40% of patients undergoing CRT fail to benefit from the treatment. A multitude of studies have shown that presence of mechanical dyssynchrony in the LV is an important factor in determining if a patient will benefit from CRT. Furthermore, recent evidence suggests that patient response can be improved by placing the LV pacing lead in the most dyssynchronous or latest contracting segment. The overall goal of this project was to develop methods that allow for accurate assessment and display of regional mechanical dyssynchrony throughout the LV and at the site of the LV pacing lead. To accomplish this goal, we developed a method for quantifying regional dyssynchrony from standard short-axis cine magnetic resonance (MR) images. To assess the effects of LV lead placement, we developed a registration method that allows us to project the LV lead location from dual-plane fluoroscopy onto MR measurements of cardiac function. By applying these techniques in patients undergoing CRT, we were able to investigate the relationship between regional dyssynchrony, LV pacing lead location, and CRT response.
dc.description.degree Ph.D.
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/50224
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Magnetic resonance imaging
dc.subject Cardiac resynchronization therapy
dc.subject Electrophysiology
dc.subject Image processing
dc.subject.lcsh Heart failure
dc.subject.lcsh Heart Magnetic resonance imaging
dc.subject.lcsh Cardiac pacing
dc.subject.lcsh Electric stimulation
dc.subject.lcsh Congestive heart failure Treatment
dc.title MRI methods for predicting response to cardiac resynchronization therapy
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Oshinski, John N.
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
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relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level Doctoral
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