Title:
Distinct Neuronal Ensembles Encode Sensory Stimulus Context in the Neocortex

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dc.contributor.author Hamm, Jordan
dc.contributor.corporatename Georgia Institute of Technology. Neural Engineering Center en_US
dc.contributor.corporatename Georgia State University. Neuroscience Institute en_US
dc.date.accessioned 2018-11-27T15:52:52Z
dc.date.available 2018-11-27T15:52:52Z
dc.date.issued 2018-11-19
dc.description Presented on November 19, 2018 at 11:15 a.m. in the Krone Engineered Biosystems Building, Room 1005. en_US
dc.description Jordan Hamm developed an interest in how EEG biomarkers relate to underlying neurobiological disease processes, a topic impossible to address with non-invasive human neuroscience methods alone. The Hamm lab conducts basic research on cortical microcircuitry with paradigms and approaches designed to provide deeper insight into neuropsychiatric disease. en_US
dc.description Runtime: 60:01 minutes en_US
dc.description.abstract The Hamm lab conducts basic research on cortical microcircuitry with paradigms and approaches designed to provide deeper insight into neuropsychiatric disease. Sensory processing abnormalities in schizophrenia (SZ) undermine how affected individuals perceive and relate to a changing environment. These aberrations reflect fundamental neural pathophysiology in SZ, impacting stable information processing and giving rise to downstream deficits in cognitive and social functioning. Dr. Hamm’s research focuses on the interaction between the cellular, circuit-level, and networks of function in the cortex i) as it relates to sensory processing dysfunction specifically, and ii) as it can provide clues toward a unifying pathophysiology in this very heterogeneous disease. His laboratory will employ techniques such as 2P-Ca++, dense array local field potential recordings (LFP/CSD), and opto/chemicogenetics in awake, behaving mice, utilizing both wild-type mice and mouse models of SZ relevant disease processes. Critically, sensory cortical structure and function is relatively well-conserved across mammals, and is highly accessible with classic psychophysical and neuroscience approaches. The Hamm lab takes advantage of this fact, employing paradigms which can be employed with human patients in clinical settings and rodent models in the lab, whereby established disease “biomarkers” (e.g. EEG measures) can be linked with specific neurobiology and therapeutics. en_US
dc.format.extent 60:01 minutes
dc.identifier.uri http://hdl.handle.net/1853/60564
dc.language.iso en_US en_US
dc.relation.ispartofseries GT Neuro Seminar Series
dc.subject Two-photon calcium imaging en_US
dc.subject Schizophrenia en_US
dc.subject Sensory processing en_US
dc.title Distinct Neuronal Ensembles Encode Sensory Stimulus Context in the Neocortex en_US
dc.type Moving Image
dc.type.genre Lecture
dspace.entity.type Publication
local.contributor.corporatename Neural Engineering Center
local.relation.ispartofseries GT Neuro Seminar Series
relation.isOrgUnitOfPublication c2e26044-257b-4ef6-8634-100dd836a06c
relation.isSeriesOfPublication 608bde12-7f29-495f-be22-ac0b124e68c5
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