Title:
Learning Neural Crest Migration at the Interface of Cell and Extracellular Matrix

dc.contributor.author Nie, Shuyi
dc.contributor.corporatename Georgia Institute of Technology. Institute for Bioengineering and Bioscience en_US
dc.contributor.corporatename Georgia Institute of Technology. School of Biological Sciences en_US
dc.date.accessioned 2017-05-26T15:13:31Z
dc.date.available 2017-05-26T15:13:31Z
dc.date.issued 2017-04-11
dc.description Presented on April 11, 2017 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering and Bioscience (IBB), room 1128, Georgia Tech. en_US
dc.description Shuyi Nie, Ph.D. is an Assistant Professor in the School of Biological Sciences, Georgia Tech. en_US
dc.description Runtime: 56:31 minutes en_US
dc.description.abstract Understanding how cells migrate during embryonic development: The fundamental question we are trying to answer is how the coordinated cell movements are regulated during animal development. Different groups of cells move to different locations in a growing embryo to give rise to specific tissue and structures. It is a very complex process since the “ground” cells travel on is also undergoing constant rearrangement and growth. We use neural crest as a model to study the mechanisms of cell migration during embryonic development. The neural crest is a vertebrate innovation, comprised of highly migratory stem-like cells that give rise to multiple tissue and structures, including craniofacial bones and cartilages, connective tissue in the heart, enteric nervous system in the gut, and pigment cells all over the skin. Defects in their proliferation, migration, differentiation, or survival lead to numerous diseases and birth defects, including craniofacial and heart malformations as well as different types of cancer. Ongoing studies aim to uncover how neural crest cell migration is regulated from several prospectives: at the level of cytoskeletal machinery, at the interface between cell and extracellular matrix, and at the level of gene transcription. We hope to understand how neural crest cells achieve such extraordinary migratory abilities, and whether such knowledge can be extended to study cancer metastasis. en_US
dc.format.extent 56:31 minutes
dc.identifier.uri http://hdl.handle.net/1853/58125
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.relation.ispartofseries Petit Institute Breakfast Club Seminar Series
dc.subject Extracellular matrix en_US
dc.subject Migration en_US
dc.subject Neural crest en_US
dc.title Learning Neural Crest Migration at the Interface of Cell and Extracellular Matrix en_US
dc.type Moving Image
dc.type.genre Lecture
dspace.entity.type Publication
local.contributor.author Nie, Shuyi
local.contributor.corporatename Parker H. Petit Institute for Bioengineering and Bioscience
local.relation.ispartofseries Petit Institute Breakfast Club Seminar Series
relation.isAuthorOfPublication 2c36c049-2d80-42bd-b62f-5b754cc74074
relation.isOrgUnitOfPublication d978f252-ad5a-4fe6-a735-21050b2d760e
relation.isSeriesOfPublication 037a6ee9-c6f0-4f20-abb8-e229d98f6754
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