Title:
Learning Neural Crest Migration at the Interface of Cell and Extracellular Matrix
Learning Neural Crest Migration at the Interface of Cell and Extracellular Matrix
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Author(s)
Nie, Shuyi
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Abstract
Understanding how cells migrate during embryonic development:
The fundamental question we are trying to answer is how the coordinated
cell movements are regulated during animal development. Different groups of
cells move to different locations in a growing embryo to give rise to specific
tissue and structures. It is a very complex process since the “ground” cells
travel on is also undergoing constant rearrangement and growth. We use
neural crest as a model to study the mechanisms of cell migration during
embryonic development. The neural crest is a vertebrate innovation,
comprised of highly migratory stem-like cells that give rise to multiple tissue
and structures, including craniofacial bones and cartilages, connective tissue
in the heart, enteric nervous system in the gut, and pigment cells all over the
skin. Defects in their proliferation, migration, differentiation, or survival lead
to numerous diseases and birth defects, including craniofacial and heart
malformations as well as different types of cancer. Ongoing studies aim to
uncover how neural crest cell migration is regulated from several
prospectives: at the level of cytoskeletal machinery, at the interface between
cell and extracellular matrix, and at the level of gene transcription. We hope
to understand how neural crest cells achieve such extraordinary migratory
abilities, and whether such knowledge can be extended to study cancer
metastasis.
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Date Issued
2017-04-11
Extent
56:31 minutes
Resource Type
Moving Image
Resource Subtype
Lecture