Electrospun Hydrogel Based Drug Delivery System for Immune Regeneration in a Cleft Palate Mice Model

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IYER-THESIS-2024.pdf (4.36 MB)
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Iyer, Keerthana Srini
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Botchwey, Edward
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Wallace H. Coulter Department of Biomedical Engineering
The joint Georgia Tech and Emory department was established in 1997
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https://hdl.handle.net/1853/75744
Abstract
Cleft palate is a developmental birth defect, defined by an abnormal space or gap formed in the upper lip or palate. This condition has high mortality rate if not treated early. Surgical correction is the current practice in the clinical field, however this comes with the risk of a secondary surgery in these patients. Wound healing takes place in a bacteria laden environment, hence increasing complications and hampers tissue regeneration. There have been many studies proving the efficacy of biomaterials as an alternative treatment plan for patients with cleft palate. Building on this finding, we developed a novel electrospun hydrogel material composed of PEGylated norbornene and thiolated hyaluronate. Developed using photo click chemistry, these materials provide an excellent scaffold for tissue regeneration, while doubling as a drug delivery carrier. The tunability of these materials facilitates in the development of a more robust material for the application of cleft palate repair, making it a potent strategy for wound healing.
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2024-07-27
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