Degradation impact on the differing Cross-Linking densities and types between SIS and PGD
Author(s)
Cantrell, Ethan
Advisor(s)
Editor(s)
Collections
Supplementary to:
Permanent Link
Abstract
This study investigates how varying crosslinking chemistries and post-thermal curing (PTC) conditions in poly(glycerol dodecanoate) (PGD)-based composites with small intestinal submucosa (SIS) influence thermal behavior, degradation profiles, and mechanical properties for soft tissue repair applications. Shape memory behavior was optimized through PTC, enabling recovery at physiological temperatures, while swelling assays confirmed that SIS thickness significantly impacts crosslinking density. Degradation studies revealed that acrylated PGD (APGD) degraded more slowly than methacrylated PGD (MPGD), correlating with retention of vinyl groups. Mechanical testing further showed that SIS thickness enhanced initial performance but made composites more susceptible to tensile deterioration during degradation—especially in APGD samples. MPGD composites demonstrated post-degradation stiffening, suggesting internal network restructuring. These findings provide critical insight into tuning scaffold properties for minimally invasive surgical delivery and soft tissue regeneration by manipulating polymer chemistry, SIS integration, and processing conditions.
Sponsor
Date
Extent
Resource Type
Text
Resource Subtype
Undergraduate Research Option Thesis