Exploiting the oxidizing capabilities of laccases for sustainable chemistry

dc.contributor.advisor Ragauskas, Arthur J.
dc.contributor.author Cannatelli, Mark Daniel
dc.contributor.committeeMember Sadighi, Joseph
dc.contributor.committeeMember Williams, Loren
dc.contributor.committeeMember Bommarius, Andreas
dc.contributor.committeeMember Deng, Yulin
dc.contributor.department Chemistry and Biochemistry
dc.date.accessioned 2017-06-07T17:47:19Z
dc.date.available 2017-06-07T17:47:19Z
dc.date.created 2017-05
dc.date.issued 2017-04-05
dc.date.submitted May 2017
dc.date.updated 2017-06-07T17:47:19Z
dc.description.abstract Enzyme catalyzed processes are rapidly becoming a viable means to accomplish chemical transformations in the field of synthetic chemistry. In an era where concern about the current and future state of the environment is at its peak, biocatalysts offer many advantages over conventional chemical catalysts, such as being nontoxic, renewable, biodegradable, highly selective, and highly active and stable in aqueous solvents at ambient temperature and neutral pH. Laccases (benzenediol:oxygen oxidoreductases, EC are a class of multi-copper oxidases that have received increasing use in recent decades as green catalytic oxidants within a variety of industries, including pulp and paper, textiles, food, cosmetics, and pharmaceuticals to name a few. They selectively oxidize electron-rich substrates, such as phenols, anilines, and benzenethiols, while concomitantly catalyzing the four electron reduction of O2 to 2H2O. Within the field of organic synthesis, laccases have been employed to catalyze a multitude of radical-radical coupling, cross-coupling, and domino reactions for the synthesis of new and existing compounds. This dissertation research has focused on harnessing the ability of laccases to generate ortho- and para-quinones in situ from the corresponding catechols and hydroquinones, respectively, which are then able to react with a variety of nucleophiles to form C-C, C-N, and C-S bonds. The developed methods have been employed for the synthesis of fine chemicals and novel lignin-derived biomaterials.
dc.description.degree Ph.D.
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/58293
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Green chemistry
dc.subject Laccases
dc.subject Lignin
dc.subject Organic synthesis
dc.subject Sustainability
dc.title Exploiting the oxidizing capabilities of laccases for sustainable chemistry
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.corporatename School of Chemistry and Biochemistry
local.contributor.corporatename College of Sciences
relation.isOrgUnitOfPublication f1725b93-3ab8-4c47-a4c3-3596c03d6f1e
relation.isOrgUnitOfPublication 85042be6-2d68-4e07-b384-e1f908fae48a
thesis.degree.level Doctoral
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