Title:
Malaria Epidemics and the Sickle-Cell Gene Dynamics
Malaria Epidemics and the Sickle-Cell Gene Dynamics
| dc.contributor.author | Feng, Zhilan | |
| dc.contributor.author | Yi, Yingfei | |
| dc.contributor.author | Zhu, Huaiping | |
| dc.contributor.corporatename | Georgia Institute of Technology. School of Mathematics | |
| dc.date.accessioned | 2009-08-10T13:52:07Z | |
| dc.date.available | 2009-08-10T13:52:07Z | |
| dc.date.issued | 2002 | |
| dc.description.abstract | A mathematical model incorporating both malaria epidemics and human population genetics of the sickle-cell gene is studied. The dynamics of the model can be separated into two time-scales with a faster time-scale for the epidemics and a slower time-scale for the change in gene frequencies. A complete analysis of the dynamics on the slow manifold is conducted, which provides insights into how malaria epidemics may have an impact on the maintenance of the sickle-cell gene in a population where malaria is prevalent. | en |
| dc.description.sponsorship | The first author is partially supported by NSF grant DMS-9974389. The second author is partially supported by NSF grant DMS-9803581. The third author is partially supported by a Canadian NSERC postdoctoral fellowship. | en |
| dc.identifier.uri | http://hdl.handle.net/1853/29484 | |
| dc.language.iso | en_US | en |
| dc.publisher | Georgia Institute of Technology | en |
| dc.relation.ispartofseries | CDSNS2002-380 | en |
| dc.subject | Malaria epidemics | en |
| dc.subject | Sickle-cell gene | en |
| dc.subject | Infective vector populations | en |
| dc.title | Malaria Epidemics and the Sickle-Cell Gene Dynamics | en |
| dc.type | Text | |
| dc.type.genre | Pre-print | |
| dspace.entity.type | Publication | |
| local.contributor.corporatename | College of Sciences | |
| local.contributor.corporatename | School of Mathematics | |
| relation.isOrgUnitOfPublication | 85042be6-2d68-4e07-b384-e1f908fae48a | |
| relation.isOrgUnitOfPublication | 84e5d930-8c17-4e24-96cc-63f5ab63da69 |