Morphological and Mechanical Behavior of Fibrin Clots in Healthy, Diabetic, and Sickle Cell Anemia Disease States

Fan, Natalie

Title:

Morphological and Mechanical Behavior of Fibrin Clots in Healthy, Diabetic, and Sickle Cell Anemia Disease States

dc.contributor.author	Fan, Natalie
dc.contributor.corporatename	Georgia Institute of Technology. Institute for Electronics and Nanotechnology	en_US
dc.contributor.corporatename	Georgia Institute of Technology. Dept. of Biomedical Engineering	en_US
dc.contributor.corporatename	Georgia Institute of Technology. School of Mechanical Engineering	en_US
dc.date.accessioned	2014-04-11T19:10:37Z
dc.date.available	2014-04-11T19:10:37Z
dc.date.issued	2014-04-08
dc.description	Natalie Fan presented a lecture at the Nano@Tech Meeting on April 8, 2014 at 12 noon in room 102 of the Joseph M. Pettit Microelectronics Research Building.	en_US
dc.description	Natalie Fan is a joint research assistant in the George W. Woodruff School of Mechanical Engineering (Prof. Rodney Averett) and the School of Biomedical Engineering (Prof. Manu Platt). She graduated from Georgia Tech with a B.S degree in Biomedical Engineering in 2013.
dc.description	Nano@Tech Special Student Presentations
dc.description	Runtime: 18:25 minutes
dc.description.abstract	Fibrinogen is an extracellular plasma protein involved in the clotting process of the vascular system. Following the initiation of the coagulation cascade in response to injury to a blood vessel, fibrinogen is converted to its active form of fibrin by the enzyme thrombin. Patients who suffer from diseases such as diabetes mellitus and sickle cell anemia have been shown to have an increased risk of developing thrombotic conditions such as heart disease, heart attacks, and strokes from higher fibrin concentration. In both of diseases, hypercoagulation and hypofibrinolysis of fibrin can induce atherothrombosis or cardiovascular disease. This study focuses on using experimental assays and confocal microscopy to determine the structural and mechanical differences of fibrin clots in these disease states compared to that of healthy patients. The results obtained from this study contribute to the understanding of underlying mechanisms involved in clotting that may lead to future developments to reduce the risk of vascular disease in diabetes and sickle cell anemia.	en_US
dc.embargo.terms	null	en_US
dc.format.extent	18:25 minutes
dc.identifier.uri	http://hdl.handle.net/1853/51591
dc.language.iso	en_US	en_US
dc.publisher	Georgia Institute of Technology	en_US
dc.relation.ispartofseries	Nano@Tech Lecture Series
dc.subject	Clotting	en_US
dc.subject	Diabetes	en_US
dc.subject	Fibrin	en_US
dc.subject	Fibrinogen	en_US
dc.subject	Nanotechnology	en_US
dc.subject	Sickle cell anemia	en_US
dc.subject	Thrombin	en_US
dc.title	Morphological and Mechanical Behavior of Fibrin Clots in Healthy, Diabetic, and Sickle Cell Anemia Disease States	en_US
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.corporatename	Institute for Electronics and Nanotechnology (IEN)
local.relation.ispartofseries	Nano@Tech Lecture Series
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relation.isSeriesOfPublication	accfbba8-246e-4389-8087-f838de8956cf