Title:
Characterizing the Elastic Properties of Naïve, Activated, and Re-Activated CD8+ T-Cells

dc.contributor.author Labrie, Morgan Rae
dc.contributor.committeeMember Sulchek, Todd
dc.contributor.committeeMember Pai, S. Balakrishna
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2019-12-06T14:49:50Z
dc.date.available 2019-12-06T14:49:50Z
dc.date.created 2018-05
dc.date.issued 2018-05
dc.date.submitted May 2018
dc.date.updated 2019-12-06T14:49:50Z
dc.description.abstract CD8+ T-cells are a crucial part of the adaptive immune system, which helps restore the body back to health when harmful pathogens such as bacteria or viruses are identified in the body. Once a pathogen is identified, CD8+ T-cells are activated and undergo a conformational change, then migrate through the body until identifying a specific antigen. The CD8+ T-cells then undergo a second activation and conformational change in order to begin fighting the pathogen. Not much is known about the mechanical properties of CD8+ T-cells during these conformational changes. This study looks at the stiffness of these cells during naïve, activated, and re-activated states through measurements taken by Atomic Force Microscopy. Evaluation of results showed that after the first activation, CD8+ T-cells become softer, and after re-activation, become more stiff, which aligns with the properties that may aid these cells in their migration and attack of pathogens. These results show promise for characterizing the relationship between stiffness and the lifecycle of CD8+ T-cells and could have future implications for potential treatments involving the immune system.
dc.description.degree Undergraduate
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/62084
dc.publisher Georgia Institute of Technology
dc.subject T-Cells
dc.subject CD8+
dc.subject Atomic Force Microscopy
dc.subject T-Cell Activation
dc.subject Dynabead
dc.title Characterizing the Elastic Properties of Naïve, Activated, and Re-Activated CD8+ T-Cells
dc.type Text
dc.type.genre Undergraduate Thesis
dspace.entity.type Publication
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename Undergraduate Research Opportunities Program
local.contributor.corporatename College of Engineering
local.relation.ispartofseries Undergraduate Research Option Theses
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 0db885f5-939b-4de1-807b-f2ec73714200
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relation.isSeriesOfPublication e1a827bd-cf25-4b83-ba24-70848b7036ac
thesis.degree.level Undergraduate
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