Nanotechnology for Ultrasensitive and Noninvasive Diagnostics

Kwong, Gabriel A.

Title:

Nanotechnology for Ultrasensitive and Noninvasive Diagnostics

dc.contributor.author	Kwong, Gabriel A.
dc.contributor.corporatename	Georgia Institute of Technology. Institute for Electronics and Nanotechnology	en_US
dc.contributor.corporatename	Georgia Institute of Technology. School of Chemical and Biomolecular Engineering	en_US
dc.date.accessioned	2015-02-05T19:08:02Z
dc.date.available	2015-02-05T19:08:02Z
dc.date.issued	2015-01-27
dc.description	Presented a lecture at the Nano@Tech Meeting on January 27, 2015 at 12 noon in room 102 A/B in the Pettit Microelectronics Building.	en_US
dc.description	Dr. Kwong is an Assistant Professor of Biomedical Engineering of Georgia Tech and Emory School of Medicine. He earned his B.S. in Bioengineering with Highest Honors from University of California at Berkeley, his Ph.D. from Caltech and postdoctoral studies at MIT. He holds 7 issued or pending patents in cancer nanotechnology.
dc.description	Runtime: 55:21 minutes
dc.description.abstract	Biomarkers are increasingly important in the clinical management of complex diseases, yet our ability to discover new biomarkers remains limited by our dependence on endogenous biomolecules. Here I describe the development of “synthetic biomarkers” comprising protease-sensitive nanoparticles that perform three functions following administration: they target sites of disease, sense dysregulated protease activities, and release reporters into the host urine as indicators of disease. These urinary reporters are mass-encoded to allow multiplexed analysis by mass spectrometry, or functionalized with capture ligands to allow detection by low-cost paper tests in global health settings. By engineering nanoparticles to sense different proteases, I show that synthetic biomarkers may be used to noninvasively monitor liver fibrosis and reversal, detect dangerous pulmonary blood clots and detect cancer earlier compared to blood biomarkers. Synthetic biomarkers have the potential to significantly expand our repertoire of diagnostic nanomedicines, and may allow systems-level analysis of multi-enzymatic networks in health and disease.	en_US
dc.embargo.terms	null	en_US
dc.format.extent	55:21 minutes
dc.identifier.uri	http://hdl.handle.net/1853/53178
dc.language.iso	en_US	en_US
dc.publisher	Georgia Institute of Technology	en_US
dc.relation.ispartofseries	Nano@Tech Lecture Series
dc.subject	Biomarkers	en_US
dc.subject	Diagnostics	en_US
dc.subject	Nanoparticles	en_US
dc.subject	Nanotechnology	en_US
dc.subject	Synthetic biomarkers	en_US
dc.title	Nanotechnology for Ultrasensitive and Noninvasive Diagnostics	en_US
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.author	Kwong, Gabriel A.
local.contributor.corporatename	Institute for Electronics and Nanotechnology (IEN)
local.relation.ispartofseries	Nano@Tech Lecture Series
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