Title:
Surface Modification of Hard PVC by Molecules with Antibacterial Activity
Surface Modification of Hard PVC by Molecules with Antibacterial Activity
Author(s)
Pigliautile, Lucrezia
Advisor(s)
Finn, M. G.
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Abstract
In this work, we present an analysis of different PVC surface modifications, attempted with the intention of attaching antibacterial small molecules, polymers, and oligomers on the plastic. These modifications allowed us to obtain intrinsically antibacterial PVC, which can be potentially applied in healthcare and medical devices. The modification was performed with two procedures, copper-catalyzed azide-alkyne cycloaddition, and nucleophilic substitution. In the first case, the surface of PVC was initially treated with sodium azide to obtain partially azidated PVC, followed by treatment with alkyne-bearing small molecules and polymers. In the second method, the surface was treated with amine-bearing small molecules and polymers, directly substituting the chlorine atoms on PVC. We concluded that the hydrophilicity, the size of the molecule, and the reaction conditions, are the main factors that influence the success of these modifications. Bacteria viability tests were performed on differently-substituted PVC samples, showing good antibacterial activities for PVC surfaces treated with quaternary ammonium salts and acceptable activities for samples modified with polyethyleneimine and oligoethylene glycol.
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Date Issued
2019-12-09
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