Title:
The role and regulation of osteopontin in hypertension related remodeling and inflammation of the aorta

dc.contributor.advisor Taylor, W. Robert
dc.contributor.author Caesar, Christa
dc.contributor.committeeMember Jo, Hanjoong
dc.contributor.committeeMember Sutliff, Roy
dc.contributor.committeeMember Davis, Michael
dc.contributor.committeeMember Gleason, Rudolph L.
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2017-06-07T17:37:06Z
dc.date.available 2017-06-07T17:37:06Z
dc.date.created 2016-05
dc.date.issued 2016-01-15
dc.date.submitted May 2016
dc.date.updated 2017-06-07T17:37:06Z
dc.description.abstract The arterial wall experiences elevated mechanical strain in the setting of hypertension, which leads to vascular inflammation and atherosclerosis. However, many of the underlying molecular mechanisms modulating this strain-dependent inflammation of the aorta are still largely unexplored. Therefore, the overall goal of this work was to analyze the specific role and regulation of the pro-inflammatory protein, osteopontin (OPN) in the aorta, in the context of hypertension. First, the expression and regulation of OPN in response to mechanical strain using an in-vitro system was evaluated. Two in-vivo models of murine hypertension were also used to determine if OPN expression was regulated via hydrogen peroxide in the setting of hypertension. Finally, we explored the contribution of OPN to the mechanical properties of the aorta under healthy and hypertensive conditions. Our results have shown that OPN is in fact up-regulated with mechanical strain in smooth muscle cells and in the aorta with hypertension via hydrogen peroxide. We have also shown that it plays an important role in mediating inflammation and remodeling of the aorta. Overall these results deepen our understanding of vascular inflammation, and have important implications in the future design of therapies and strategies aimed against the consequences of hypertension such as atherosclerosis.           
dc.description.degree Ph.D.
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/58157
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Osteopontin
dc.subject Hypertension
dc.subject Aorta
dc.subject Mechanical strain
dc.subject Hydrogen peroxide
dc.title The role and regulation of osteopontin in hypertension related remodeling and inflammation of the aorta
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Taylor, W. Robert
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 61ce23da-1f00-4546-85ff-bf6b236680eb
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level Doctoral
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