Title:
Study of Mixed Lipid Bilayer System using Molecular Dynamics Simulation

dc.contributor.author Choi, Jae Hyung
dc.contributor.committeeMember Jang, Seung Soon
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2015-02-03T18:06:35Z
dc.date.available 2015-02-03T18:06:35Z
dc.date.created 2014-12
dc.date.issued 2015-01-28
dc.date.submitted December 2014
dc.date.updated 2015-02-03T18:06:35Z
dc.description.abstract For most of the pharmaceutical industry’s existence, there have been many efforts to develop a cure for treating cancer. However, we are still years away from any possible cure for cancer, and available treatments have many obstacles to overcome. Specifically, chemotherapy has significant issues in delivering the required dosage of drugs to the cancer site. One of the disadvantages is that large amounts of drugs are required to be injected in order to overcome various obstacles including the circulatory system. However, due to toxicity, there is a limitation on the administered dosage allowed. To solve this problem, smart drug delivery systems have been developed. Encapsulating chemotherapy drugs inside synthesized carriers such as liposomes can reduce toxicity by shielding the drug from contacting healthy cells. One of the goals is to create a type of release mechanism at the cancer site. Releasing a chemotherapy drug at a specific site will make it possible to deliver appropriate doses of drugs without causing high toxicity. To study how carriers act inside the body, Molecular Dynamics (MD) simulation can be incorporated.
dc.description.degree Undergraduate
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/53173
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Molecular dynamics simulation
dc.subject MD simulation
dc.subject Lipid bilayer
dc.subject DPPC
dc.subject MPPC
dc.title Study of Mixed Lipid Bilayer System using Molecular Dynamics Simulation
dc.type Text
dc.type.genre Undergraduate Thesis
dspace.entity.type Publication
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename Undergraduate Research Opportunities Program
local.contributor.corporatename College of Engineering
local.relation.ispartofseries Undergraduate Research Option Theses
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relation.isOrgUnitOfPublication 0db885f5-939b-4de1-807b-f2ec73714200
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relation.isSeriesOfPublication e1a827bd-cf25-4b83-ba24-70848b7036ac
thesis.degree.level Undergraduate
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