Title:
Micromachined three-dimensional electrode arrays for in-vitro and in-vivo electrogenic cellular networks

Simple item page
dc.contributor.advisor Allen, Mark G.
dc.contributor.author Rajaraman, Swaminathan en_US
dc.contributor.committeeMember Elliot L. Chaikof
dc.contributor.committeeMember Ionnis (John) Papapolymerou
dc.contributor.committeeMember Maysam Ghovanloo
dc.contributor.committeeMember Oliver Brand
dc.contributor.department Electrical and Computer Engineering en_US
dc.date.accessioned 2009-06-08T19:01:52Z
dc.date.available 2009-06-08T19:01:52Z
dc.date.issued 2009-04-06 en_US
dc.description.abstract This dissertation presents an investigation of micromachined three-dimensional microelectrode arrays (3-D MEAs) targeted toward in-vitro and in-vivo biomedical applications. Current 3-D MEAs are predominantly silicon-based, fabricated in a planar fashion, and are assembled to achieve a true 3-D form: a technique that cannot be extended to micro-manufacturing. The integrated 3-D MEAs developed in this work are polymer-based and thus offer potential for large-scale, high volume manufacturing. Two different techniques are developed for microfabrication of these MEAs - laser micromachining of a conformally deposited polymer on a non-planar surface to create 3-D molds for metal electrodeposition; and metal transfer micromolding, where functional metal layers are transferred from one polymer to another during the process of micromolding thus eliminating the need for complex and non-repeatable 3-D lithography processes. In-vitro and in-vivo 3-D MEAs are microfabricated using these techniques and are packaged utilizing Printed Circuit Boards (PCB) or other low-cost manufacturing techniques. To demonstrate in-vitro applications, growth of 3-D co-cultures of neurons/astrocytes and tissue-slice electrophysiology with brain tissue of rat pups were implemented. To demonstrate in-vivo application, measurements of nerve conduction were implemented. Microelectrode impedance models, noise models and various process models were evaluated. The results confirmed biocompatibility of the polymers involved, acceptable impedance range and noise of the microelectrodes, and potential to improve upon an archaic clinical diagnostic application utilizing these 3-D MEAs. en_US
dc.description.degree Ph.D. en_US
dc.identifier.uri http://hdl.handle.net/1853/28129
dc.publisher Georgia Institute of Technology en_US
dc.subject Metal transfer micromolding en_US
dc.subject MEMS en_US
dc.subject Micromachining en_US
dc.subject Three-Dimensional Microelectrode Arrays (3-D MEAS) en_US
dc.subject Biocompatible MEMS en_US
dc.subject In-vitro tissue slice electrophysiology en_US
dc.subject Neurotechnology en_US
dc.subject Microelectrode impedance en_US
dc.subject Biomedical en_US
dc.subject Laser micromachining en_US
dc.subject In-vivo nerve tracking en_US
dc.subject.lcsh Microelectrodes
dc.subject.lcsh Biosensors
dc.subject.lcsh Polymers in medicine
dc.title Micromachined three-dimensional electrode arrays for in-vitro and in-vivo electrogenic cellular networks en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.corporatename School of Electrical and Computer Engineering
local.contributor.corporatename College of Engineering
relation.isOrgUnitOfPublication 5b7adef2-447c-4270-b9fc-846bd76f80f2
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
rajaraman_swaminathan_200905_phd.pdf.pdf
Size:
20.49 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Theses and Dissertations