Title:
The loading and function of the mitral valve under normal, pathological and repair conditions: an in vitro study

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dc.contributor.advisor Yoganathan, Ajit P.
dc.contributor.author Jimenez-Mejia, Jorge Hernan en_US
dc.contributor.committeeMember Joseph Gorman
dc.contributor.committeeMember Oshinski, John
dc.contributor.committeeMember Marc Levenston
dc.contributor.committeeMember Thomas Vassiliades
dc.contributor.department Biomedical Engineering en_US
dc.date.accessioned 2007-03-27T18:17:18Z
dc.date.available 2007-03-27T18:17:18Z
dc.date.issued 2006-11-16 en_US
dc.description.abstract Currently, mitral valve repair techniques have shown substandard mid-term and long term results. In order to improve the efficacy of these repair techniques, detailed knowledge of normal mitral valve function and the alterations to the valvular and subvalvular apparatus which occur under pathological conditions is required. Furthermore, current techniques may be optimized through a better understanding of the function and mechanics of the mitral valve after a particular repair. The experiments which comprise this study were designed using an in vitro approach since this technique has the clear advantage of isolating and independently controlling specific parameters that are of importance to valvular mechanics and function. The experiments were conducted in the Georgia Tech Left Heart Simulator using native porcine and human mitral valves. The first set of experiments measured the chordal force distribution and anterior leaflet strain of the mitral valve in its normal geometrical configuration. Subsequent experiments measure mitral regurgitation volume and chordal force distribution in conditions associated with ventricular dilation. The last set of experiments simulated two commonly used mitral repair techniques. For the Alfieri stitch experiments, the effects of mitral flow rate, transmitral pressure, and mitral annular area on valve stenosis, mitral regurgitation and Alfieri stitch force were evaluated. For annuloplasty, the effect of annular saddle curvature on anterior leaflet strain was quantified. In Conclusion, the normal geometry of the native mitral valve optimized its function and mechanics. Under pathological conditions associated with ventricular dilation, significant alterations to mitral valve function and mechanics were present. Although the studied repair techniques may have significantly restored valve function, severe alterations to the mechanics of the valve still persisted. en_US
dc.description.degree Ph.D. en_US
dc.format.extent 3573077 bytes
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/14034
dc.language.iso en_US
dc.publisher Georgia Institute of Technology en_US
dc.subject Chordae tendineae en_US
dc.subject Mitral valve en_US
dc.subject Heart valve en_US
dc.subject Heart en_US
dc.subject Cardiovascular mechanics en_US
dc.subject.lcsh Heart valves Diseases en_US
dc.subject.lcsh Mitral valve Diseases en_US
dc.subject.lcsh Cardiology, Experimental en_US
dc.subject.lcsh Chordae tendineae en_US
dc.title The loading and function of the mitral valve under normal, pathological and repair conditions: an in vitro study en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Yoganathan, Ajit P.
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 6a910742-4bed-4ba6-b03d-f92e4c915a00
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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