Title:
Bio-functionalized peg-maleimide hydrogel for vascularization of transplanted pancreatic islets

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dc.contributor.advisor García, Andrés J.
dc.contributor.author Phelps, Edward Allen en_US
dc.contributor.committeeMember Murthy, Niren
dc.contributor.committeeMember Sambanis, Athanassios
dc.contributor.committeeMember Taylor, W Robert
dc.contributor.committeeMember Temenoff, Johnna
dc.contributor.committeeMember Thulé, Peter
dc.contributor.department Bioengineering en_US
dc.date.accessioned 2013-01-17T21:59:29Z
dc.date.available 2013-01-17T21:59:29Z
dc.date.issued 2011-11-08 en_US
dc.description.abstract Type 1 diabetes affects one in every 400-600 children and adolescents in the US. Standard therapy with exogenous insulin is burdensome, associated with a significant risk of dangerous hypoglycemia, and only partially efficacious in preventing the long term complications of diabetes. Pancreatic islet transplantation has emerged as a promising therapy for type 1 diabetes. However, this cell-based therapy is significantly limited by inadequate islet supply (more than one donor pancreas is needed per recipient), instant blood-mediated inflammatory reaction, and loss of islet viability/function during isolation and following implantation. In particular, inadequate revascularization of transplanted islets results in reduced islet viability, function, and engraftment. Delivery of pro-vascularization factors has been shown to improve vascularization and islet function, but these strategies are hindered by insufficient and/or complex release pharmacokinetics and inadequate delivery matrices as well as technical and safety considerations. We hypothesized that controlled presentation of angiogenic cues within a bioartificial matrix could enhance the vascularization, viability, and function of transplanted islets. The primary objective of this dissertation was to enhance allogenic islet engraftment, survival and function by utilizing synthetic hydrogels as engineered delivery matrices. Polyethylene glycol (PEG)-maleimide hydrogels presenting cell adhesive motifs and vascular endothelial growth factor (VEGF) were designed to support islet activities and promote vascularization in vivo. We analyzed the material properties and cyto-compatibility of these engineered materials, islet engraftment in a transplantation model, and glycemic control in diabetic subjects. The rationale for this project is to establish novel biomaterial strategies for islet delivery that support islet viability and function via the induction of local vascularization. en_US
dc.description.degree PhD en_US
dc.identifier.uri http://hdl.handle.net/1853/45899
dc.publisher Georgia Institute of Technology en_US
dc.subject Vascularization en_US
dc.subject Transplantation en_US
dc.subject Polyethylene glycol en_US
dc.subject Hydrogel en_US
dc.subject Pancreatic islet en_US
dc.subject Maleimide en_US
dc.subject.lcsh Colloids
dc.subject.lcsh Islands of Langerhans
dc.subject.lcsh Pancreas
dc.subject.lcsh Regenerative medicine
dc.title Bio-functionalized peg-maleimide hydrogel for vascularization of transplanted pancreatic islets en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor García, Andrés J.
local.contributor.corporatename College of Engineering
local.contributor.corporatename College of Engineering
local.relation.ispartofseries Doctor of Philosophy with a Major in Bioengineering
relation.isAdvisorOfPublication 6236e450-228b-4532-8b5e-812316ac90f3
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
relation.isSeriesOfPublication 5db25cda-aa52-48d2-8f63-c551ef2c92f4
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