Title:
The Nanoscale Biointerface and Healing Biomaterials

dc.contributor.author Ratner, Buddy D.
dc.contributor.corporatename Georgia Institute of Technology. Institute for Bioengineering and Bioscience
dc.contributor.corporatename University of Washington. Engineered Biomaterials
dc.date.accessioned 2009-07-21T18:28:35Z
dc.date.available 2009-07-21T18:28:35Z
dc.date.issued 2002-10-03
dc.description Buddy Ratner of the University of Washington Engineering, Biomaterials Center presented a lecture on October 3, 2002 at 11:00 am in the Suddath Seminar Room, IBB Building, Georgia Tech Campus. en
dc.description.abstract Implantable medical devices, and the biomaterials that comprise them, are measured on macro scales (centimeters). Yet the biocompatibility of such devices may be dictated by phenomena best described at nanometer dimensions. Biomedical implants and the University of Washington Engineered Biomaterials (UWEB) Engineering Research Center will be introduced. The classical definition of biocompatibility will be contrasted to a newer definition embracing nanomolecular concepts. Biological data on the in vivo healing responses of mammals to matricellular proteins such as osteopontin, thrombospondin 2 and SPARC will be presented with an emphasis on exploiting the special reactivity of such proteins. First, non-specific protein adsorption must be inhibited. Strategies to achieve this design parameter will be presented. Then methods to deliver the specific protein signals will be addressed. An imprinting approach and a self-assembly approach will be described. Finally, speculation on how such materials that precisely control interfacial biological reactions will be used in medicine will complete this lecture. Modern surface analysis techniques that can address the complexity of a functional biointerface will be highlighted to define nanostructures. en
dc.format.extent 60:36 minutes
dc.identifier.uri http://hdl.handle.net/1853/29011
dc.language.iso en_US en
dc.publisher Georgia Institute of Technology en
dc.relation.ispartofseries Bioengineering Seminar Series
dc.subject Biomedical implants en
dc.subject Biomaterials that heal en
dc.subject Biocompatibility en
dc.subject Nanoscale biointerface
dc.subject Nanotechnology
dc.title The Nanoscale Biointerface and Healing Biomaterials en
dc.type Moving Image
dc.type.genre Lecture
dspace.entity.type Publication
local.contributor.corporatename Parker H. Petit Institute for Bioengineering and Bioscience
local.relation.ispartofseries Bioengineering Seminar Series
relation.isOrgUnitOfPublication d978f252-ad5a-4fe6-a735-21050b2d760e
relation.isSeriesOfPublication 18dd4e39-e654-41a4-bc7a-9c97320c4730
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