Investigation of Novel Modification of Poly(Glycerol)Dodecanedioate with Methacrylic Anhydride for Biomedical Applications
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Kulagin, Valerii
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Abstract
Currently there is a gap in tissue engineering for the development of biomaterials that can be deployed via minimally invasive surgical (MIS) technologies and fit for soft tissue pathologies. Even with this gap in the field, MIS procedures are used more and more often due to lower costs, decreased length of hospitalization, and fewer side effects. The main challenges with development of these biomaterials are mechanical compatibility, biodegradability, and biocompatibility. Two other important factors for materials used in MIS are shape memory properties and 3D printability, which most materials do not possess. Hollister lab has developed poly(glycerol)dodecanedioate (PGD). Its viscoelastic properties, shape memory properties and relevant transition temperature in combination with proven biocompatibility and biodegradability make it a good fit for MIS procedures. Recently a novel version of the polymer has become available - acrylated PGD (APGD). APGD has a different structure than PGD due to the added acryloyl group. It therefore has the capability to crosslink at room temperature upon application of UV light. This is a major advancement compared to regular PGD which cannot be 3D printed. However, in order for the polymer to become widely adopted it has to have a scalable synthesis procedure. In this paper a new modification of PGD polymer called methacrylated PGD (MPGD) is reported. It doesn’t yield salts as byproducts and limits auto-polymerization during reaction which in turn allows to achieve high methacrylation percentages and high yield, which eventually can be used for mass production. This work is not only describes the synthesis procedure, but also to the properties of crosslinked MPGD polymer including its thermal properties (transition temperature, enthalpy), swelling data (gel content, swelling ratio), degradation profile and raw MPGD polymer’s chemical structure (NMR signatures).
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Undergraduate Thesis