Title:
An object oriented environment for artificial evolution of protein sequences: The example of rational design of transmembrane sequences

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dc.contributor.author Milik, Mariusz
dc.contributor.author Skolnick, Jeffrey
dc.contributor.corporatename Georgia Institute of Technology. Center for the Study of Systems Biology
dc.contributor.corporatename Georgia Institute of Technology. School of Biology
dc.date.accessioned 2011-11-09T19:31:43Z
dc.date.available 2011-11-09T19:31:43Z
dc.date.issued 1995
dc.description ©1995 Massachusetts Institute of Technology Press en_US
dc.description Presented at Evolutionary Programming IV: Proceedings of the Fourth Annual Conference on Evolutionary Programming, March 1-3, 1995, San Diego, California. en_US
dc.description.abstract A system is presented for generating peptide sequences with desirable properties, using combination of neural network and artificial evolution. The process is illustrated by an example of a practical problem of generating artificial transbilayer peptides. The peptides generated in the process of artificial evolution have the physico-chemical properties of transmembrane peptides, and forms stable transmembrane structures in testing Monte Carlo simulations. The artificial evolution system is designed to emulate natural evolution; therefore it is of both practical and theoretical interest, both in terms of rational design of protein sequences and modeling of natural evolution of proteins. en
dc.identifier.citation Milik, M, Skolnick J. 1995. An object oriented environment for artificial evolution of protein sequences: The example of rational design of transmembrane sequences. Evolutionary Conference. en
dc.identifier.isbn 262133172
dc.identifier.uri http://hdl.handle.net/1853/41970
dc.language.iso en_US en
dc.publisher Georgia Institute of Technology en
dc.publisher.original Massachusetts Institute of Technology Press
dc.subject Peptide sequences en
dc.subject Neural networks en
dc.subject Artificial evolution en
dc.subject Monte Carlo method en
dc.subject Mathematical models en
dc.title An object oriented environment for artificial evolution of protein sequences: The example of rational design of transmembrane sequences en_US
dc.type Text
dc.type.genre Proceedings
dspace.entity.type Publication
local.contributor.author Skolnick, Jeffrey
local.contributor.corporatename College of Sciences
local.contributor.corporatename School of Biological Sciences
local.contributor.corporatename Center for the Study of Systems Biology
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