Title:
An object oriented environment for artificial evolution of protein sequences: The example of rational design of transmembrane sequences
An object oriented environment for artificial evolution of protein sequences: The example of rational design of transmembrane sequences
Author(s)
Milik, Mariusz
Skolnick, Jeffrey
Skolnick, Jeffrey
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Abstract
A system is presented for generating peptide sequences with desirable properties,
using combination of neural network and artificial evolution. The
process is illustrated by an example of a practical problem of generating
artificial transbilayer peptides. The peptides generated in the process of
artificial evolution have the physico-chemical properties of transmembrane
peptides, and forms stable transmembrane structures in testing Monte Carlo
simulations. The artificial evolution system is designed to emulate natural
evolution; therefore it is of both practical and theoretical interest, both in
terms of rational design of protein sequences and modeling of natural evolution
of proteins.
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Date Issued
1995
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Text
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Proceedings