Harnessing In Vivo Enzymatic Activity to Engineer Synthetic Breath Biomarkers of Disease

Chan, Leslie

Title:

Harnessing In Vivo Enzymatic Activity to Engineer Synthetic Breath Biomarkers of Disease

dc.contributor.author	Chan, Leslie
dc.contributor.corporatename	Georgia Institute of Technology. Institute for Electronics and Nanotechnology	en_US
dc.contributor.corporatename	Georgia Institute of Technology. Wallace H. Coulter Department of Biomedical Engineering	en_US
dc.date.accessioned	2022-04-07T01:43:10Z
dc.date.available	2022-04-07T01:43:10Z
dc.date.issued	2022-03-29
dc.description	Presented on March 29, 2022 from 12:00 p.m.-1:00 p.m. in the Marcus Nanotechnology Building, Rooms 1116-1118, Georgia Tech, Atlanta, GA.	en_US
dc.description	Leslie Chan is an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Tech School of Engineering and Emory School of Medicine. Chan earned her B.S. in biomedical engineering from Georgia Tech and her Ph.D. in bioengineering from the University of Washington with Professor Suzie Pun. She completed her postdoctoral training at Massachusetts Institute of Technology with Professor Sangeeta Bhatia and is a recipient of an NIH K99/R00 award. Chan’s research program uses emerging principles from nanomedicine to develop technologies to study, detect, and treat infectious disease, microbiome dysbiosis, and inflammatory diseases.	en_US
dc.description	Runtime: 34:10 minutes	en_US
dc.description.abstract	Breath testing is a non-invasive and rapid diagnostic tool that is underutilized in the clinic due to scarcity of known breath biomarkers. Thousands of volatile organic compounds (VOCs) are excreted from the body in breath after having been produced endogenously as volatile metabolites or introduced exogenously via diet or environmental exposure. However, efforts to identify disease-specific VOCs have been hindered by technological and statistical limitations with currently-used -omic approaches. As an alternative approach to biomarker discovery, my lab has developed a diagnostic platform that leverages aberrant enzymatic activity during disease to engineer synthetic breath biomarkers. This platform technology consists of nanoparticle sensors that are delivered in vivo and release bio-orthogonal VOC reporters upon activation by targeted enzymatic activity. VOC trafficking pathways from tissues to breath offers a mechanism by which we can engineer exhaled biomarkers for diseases of different organ systems. In my talk, I will discuss how we designed and validated our volatile-releasing nanosensors for use in respiratory disease and future applications in gastrointestinal disease.	en_US
dc.format.extent	34:10 minutes
dc.identifier.uri	http://hdl.handle.net/1853/66361
dc.language.iso	en_US	en_US
dc.publisher	Georgia Institute of Technology	en_US
dc.relation.ispartofseries	Nano@Tech Lecture Series
dc.subject	Biomarkers	en_US
dc.subject	Enzymatic activity	en_US
dc.subject	Volatile organic compounds	en_US
dc.title	Harnessing In Vivo Enzymatic Activity to Engineer Synthetic Breath Biomarkers of Disease	en_US
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.corporatename	Institute for Electronics and Nanotechnology (IEN)
local.relation.ispartofseries	Nano@Tech Lecture Series
relation.isOrgUnitOfPublication	5d316582-08fe-42e1-82e3-9f3b79dd6dae
relation.isSeriesOfPublication	accfbba8-246e-4389-8087-f838de8956cf