Title:
Aza-peptide Epoxides

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dc.contributor.patentcreator Powers, James C.
dc.contributor.patentcreator Glass, Jonathan D.
dc.date.accessioned 2017-05-12T14:29:06Z
dc.date.available 2017-05-12T14:29:06Z
dc.date.filed 1/24/2006
dc.date.issued 9/6/2011
dc.description.abstract Methods for treatment and/or prevention of nerve degeneration in mammals using aza-peptide epoxide caspase inhibitors are provided. Aspects of the present disclosure include aza-peptide epoxide compositions to treat or prevent diseases, for example stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidoluysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, diabetes, amyotrophic lateral sclerosis and other motor neuron diseases. The disclosed methods can be used in combination with calpain inhibitors to treat disease or pathological conditions related to the activity of caspases and calpain associated with a specific disease or condition. Such treatable conditions include stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidoluysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, nerve degeneration associated with diabetes, amyotrophic lateral sclerosis and other motor neuron diseases, nerve degeneration secondary to primary demyelinating disorders, among others.
dc.description.assignee Georgia Tech Research Corporation
dc.identifier.cpc A61K31/336
dc.identifier.cpc A61K31/401
dc.identifier.cpc A61K31/405
dc.identifier.patentapplicationnumber 11/338147
dc.identifier.patentnumber 8013014
dc.identifier.uri http://hdl.handle.net/1853/57983
dc.identifier.uspc 514/475
dc.title Aza-peptide Epoxides
dc.type Text
dc.type.genre Patent
dspace.entity.type Publication
local.contributor.corporatename Georgia Institute of Technology
local.relation.ispartofseries Georgia Tech Patents
relation.isOrgUnitOfPublication cc30e153-7a64-4ae2-9b1d-5436686785e3
relation.isSeriesOfPublication 0f49c79d-4efb-4bd9-b060-5c7f9191b9da
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