Title:
Assessing the Genotoxic Effects of Microparticulate Exposure in Drosophila Melanogaster

dc.contributor.author Kabir, Fahim
dc.contributor.author Snell, Terry W.
dc.contributor.author Danielson, Chris
dc.date.accessioned 2013-06-17T17:53:36Z
dc.date.available 2013-06-17T17:53:36Z
dc.date.issued 2011
dc.description The Tower is an official publication of the Georgia Tech Office of Student Media and is sponsored by the Undergraduate Research Opportunities Program and the Georgia Tech Library. This article appeared in Volume 3, pages 61-67. en_US
dc.description.abstract Exposure to microparticulate matter and endocrine disruptors has been linked to severe pathological and disruptive effects on human health. Airborne microparticles are confirmed vectors for various pulmonary and cardiovascular conditions as well as adverse genotoxic and cytotoxic effects. Endocrine disruptors are especially detrimental since they selectively interfere with the sex hormone functions of the host organism and can potentially disrupt ecosystems by hindering reproduction in affected species. Despite the fact that there are numerous studies assessing the cytotoxic effects of airborne microparticulate matter, there is a clear deficiency of conclusive data and topical research assessing the genotoxic effects of microparticles on organisms. The aim of this study was to evaluate the significance of microparticulate exposure in an urbanized setting in order to assess whether anthropogenic causes are producing detrimentally quantifiable genotoxic effects and possibly endocrine disruption. Drosophila melanogaster was used as a model test subject to analyze for survivorship, induced genotoxicity, and distorted sex ratios across generations. Samples of microparticulate matter were collected from four locations of varying degrees of urbanization and incorporated into the parental generation and observed over two generations. Microparticulate exposure did in fact have an observable generational selection effect on D. melanogaster. We also observed distorted sex ratios in the F1 generation; however, endocrine disruption was not attributable to exposure. Based on a comet assay, we found clear indications that genotoxic damage was linked to the extent of microparticulate exposure. en_US
dc.description.sponsorship Office of Student Media; Undergraduate Research Opportunities Program; Georgia Tech Library. en_US
dc.embargo.terms null en_US
dc.identifier.uri http://hdl.handle.net/1853/47773
dc.language.iso en en_US
dc.publisher Georgia Institute of Technology en_US
dc.relation.ispartofseries The Tower. Volume 3, Spring 2011
dc.title Assessing the Genotoxic Effects of Microparticulate Exposure in Drosophila Melanogaster en_US
dc.type Text
dc.type.genre Article
dspace.entity.type Publication
local.contributor.author Snell, Terry W.
local.contributor.corporatename Undergraduate Research Opportunities Program
relation.isAuthorOfPublication 0c435f8e-a5e5-49b9-b135-99f3d90a0910
relation.isOrgUnitOfPublication 0db885f5-939b-4de1-807b-f2ec73714200
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