Title:
Nanoparticle-mediated functional and molecular photoacoustic imaging for assessment of metastatic lymph nodes

dc.contributor.advisor Emelianov, Stanislav
dc.contributor.author Dumani Jarquin, Diego Sayed
dc.contributor.committeeMember Lindsey, Brooks
dc.contributor.committeeMember Robles, Francisco
dc.contributor.committeeMember Yang, Lily
dc.contributor.committeeMember Fei, Baowei
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2019-01-16T17:25:27Z
dc.date.available 2019-01-16T17:25:27Z
dc.date.created 2018-12
dc.date.issued 2018-11-14
dc.date.submitted December 2018
dc.date.updated 2019-01-16T17:25:27Z
dc.description.abstract Despite advances in prevention, detection, and treatment of cancer, this disease remains the second leading cause of death in the United States. The majority of cancer related deaths are due to metastasis rather than primary tumors and, although mortality rates have decreased over the last two decades, efforts to achieve comprehensive diagnoses and effective treatments still encounter obstacles due to lack of non-invasive technologies that accurately assess cancer. The goal of this project is to design a non invasive approach for the assessment of sentinel lymph node metastasis using ultrasound and photoacoustic imaging, augmented with contrast agents. The focus is two-fold: first, contrast enhanced ultrasound and photoacoustic imaging are evaluated as a tool to track functional and molecular changes of metastatic lymph nodes in relevant in vivo cancer models. Specifically, imaging of immune cell uptake and transport of lymphotropic nanoparticles to the sentinel lymph node, and imaging of clearable nanoparticles targeted to the epidermal growth factor receptor provide diagnostic information regarding metastatic nodal involvement. Second, alternative contrast agents are designed with the goal of solving challenges of the proposed techniques and augmenting therapeutic capabilities. Overall, the study is expected to help identify cancer based on functional and molecular changes, therefore augmenting and potentially replacing sentinel lymph node biopsy.
dc.description.degree Ph.D.
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/60810
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Photoacoustic imaging
dc.subject Ultrasound
dc.subject Nanoparticles
dc.subject Contrast agents
dc.subject Lymph node
dc.subject Metastasis
dc.subject Cancer
dc.subject Functional imaging
dc.subject Molecular imaging
dc.subject Lymphatics
dc.subject Biopsy
dc.title Nanoparticle-mediated functional and molecular photoacoustic imaging for assessment of metastatic lymph nodes
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Emelianov, Stanislav
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 0191ee0f-a916-4fb2-ba53-c4d82a3fafa7
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level Doctoral
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