Title:
Microdermabrasion for transdermal drug delivery

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dc.contributor.advisor Prausnitz, Mark R.
dc.contributor.author Andrews, Samantha Nacole en_US
dc.contributor.committeeMember Eric Tomlinson
dc.contributor.committeeMember Gilda Barabino
dc.contributor.committeeMember Babensee, Julia
dc.contributor.committeeMember Murthy, Niren
dc.contributor.committeeMember Richard Compans
dc.contributor.department Biomedical Engineering en_US
dc.date.accessioned 2011-03-04T20:17:24Z
dc.date.available 2011-03-04T20:17:24Z
dc.date.issued 2010-08-27 en_US
dc.description.abstract The skin serves as a semi-permeable barrier that protects the body from pathogens and water loss. The stratum corneum, the upper 10-15 µm layer of skin, is the primary barrier layer. Due to its structure, only drugs that are lipophilic and with a low molecular weight (<500 Da) can penetrate intact skin. This study examines the use of microdermabrasion as a method of removing the stratum corneum to increase the skin's permeability to hydrophilic molecules, proteins, and vaccines. Microdermabrasion is a FDA-approved cosmetic skin resurfacing procedure that removes the stratum by bombarding it with abrasive particles under vacuum. The aims of this thesis are focused on optimizing the microdermabrasion conditions that will selectively remove stratum corneum, evaluating the transport of different sized molecules through abraded skin in vitro, examining drug efficacy in vivo by delivering insulin to diabetic rats, and examining the rate of skin healing after treatment. Microdermabrasion can be used as a non-invasive transdermal drug technique to safely remove stratum corneum to make the skin more permeable to waters soluble drugs and proteins. en_US
dc.description.degree Ph.D. en_US
dc.identifier.uri http://hdl.handle.net/1853/37150
dc.publisher Georgia Institute of Technology en_US
dc.subject Microdermabrasion en_US
dc.subject Transdermal drug delivery en_US
dc.subject Skin en_US
dc.subject.lcsh Transdermal medication
dc.title Microdermabrasion for transdermal drug delivery en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Prausnitz, Mark R.
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 4bd611de-763a-4e92-abdc-0558443485cc
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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