Cell-by-Cell Monte Carlo Modeling of Chromosome Aberrations and Cell Death Induced by 250-kVp X-Rays and Co-60 Gamma Rays
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Seppings, Anna
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Abstract
Employing the In-Silico research methodology developed by the Georgia Institute of
Technology, an investigation into the interplay between dose rate, chromosome aberrations, misrepairs, and cell survival is outlined. This computational approach utilizes virtual methodologies to efficiently and effectively simulate in-vitro experiments. The simulated
scenarios involve the irradiation of cell cultures with 250-kVp x-rays and Co-60 gamma rays across varying doses and dose rates. The discerned data indicates an increased frequency of chromosome aberrations in cells exposed under high-dose and high-dose-rate conditions. Furthermore, the cell survival curve for cells subjected to elevated dose rates conforms to the quadratic component of the linear quadratic model for cell survival, while cells exposed under low-dose-rate conditions predominantly manifest the linear component.
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2024-01-16
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