Towards an Evolutionary Synthetic Biology

Gaucher, Eric A.

Title:

Towards an Evolutionary Synthetic Biology

dc.contributor.author	Gaucher, Eric A.
dc.contributor.corporatename	Georgia Institute of Technology. Institute for Bioengineering and Bioscience
dc.date.accessioned	2009-12-09T20:54:36Z
dc.date.available	2009-12-09T20:54:36Z
dc.date.issued	2009-11-10
dc.description	Presented on November 10, 2009 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering & Bioscience (IBB), room 1128, Georgia Tech.	en
dc.description.abstract	Evolution is the unifying theory behind biology, and has entered the mainstream of computational and molecular biology as a result of genomics. Nevertheless, evolutionary ideas today only barely influence the practice of molecular sciences. Innovation in many areas will be required before evolutionary analyses provide utility to biomedicine and biotechnology. Research in our laboratory attempts to enhance our understanding of evolutionary processes and structure-function relationships in the long-term, while also generating novel biomolecules having technological and therapeutic value in the short-term. If successful, these innovations will add utility to genome sequence data far beyond that found in comparative genomics. Using information extracted from molecular evolutionary analyses to guide the engineering of proteins is an innovative addition to existing methods. If evolution-guided engineering can deliver biomolecular properties not otherwise attainable with traditional engineering/directed evolution techniques, then this approach will have wide utility. The above activities form the foundation of our attempt to develop an evolutionary synthetic biology. We are energized by the prospect of joining evolutionary biology and synthetic biology. Synthetic biology appears to mean different things to different scientific disciplines. Surprisingly, however, biologists seem to have taken a backseat to chemists and engineers in the development of this field. It seems apparent that synthetic biology would stand to benefit if molecular evolution contributed to its progress.	en
dc.format.extent	61:52 minutes
dc.identifier.uri	http://hdl.handle.net/1853/31346
dc.language.iso	en_US	en
dc.publisher	Georgia Institute of Technology	en
dc.relation.ispartofseries	Petit Institute Breakfast Club Seminar Series
dc.subject	Biomedicine	en
dc.subject	Biotechnology	en
dc.subject	Evolutionary processes	en
dc.subject	Genomics	en
dc.subject	Molecular evolution	en
dc.subject	Proteins	en
dc.title	Towards an Evolutionary Synthetic Biology	en
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.corporatename	Parker H. Petit Institute for Bioengineering and Bioscience
local.relation.ispartofseries	Petit Institute Breakfast Club Seminar Series
relation.isOrgUnitOfPublication	d978f252-ad5a-4fe6-a735-21050b2d760e
relation.isSeriesOfPublication	037a6ee9-c6f0-4f20-abb8-e229d98f6754