Title:
Multicontrast MRI of Atherosclerotic Plaques: Acquisition, Characterization and Reconstruction

Simple item page
dc.contributor.advisor Giddens, Don P.
dc.contributor.advisor Oshinski, John N.
dc.contributor.author Sun, Binjian en_US
dc.contributor.committeeMember Raymond P. Vito
dc.contributor.committeeMember Robert C. Long, Jr.
dc.contributor.committeeMember Taylor, W. Robert
dc.contributor.department Biomedical Engineering en_US
dc.date.accessioned 2007-08-16T17:58:19Z
dc.date.available 2007-08-16T17:58:19Z
dc.date.issued 2007-06-22 en_US
dc.description.abstract Cardiovascular Disease (CVD) continues to be the leading cause of death in western countries according to the statistics update by the American Heart Association. Atherosclerosis is estimated to be responsible for a large portion of CVD and affects 60 million people in the United States. Accurate diagnosis is crucial for proper treatment planning. Currently, the clinical standard screening technique for diagnosing atherosclerosis is x-ray angiography, which reveals the residual lumen size. X-ray angiographic images possess good resolution and contrast, however, lumen size is not always a proper criterion given the positive remodeling nature of atherosclerotic plaques. In the past decade, it has been shown that most plaques responsible for a fatal or nonfatal myocardial infarction are less than 70% stenosed. Clinical data support the idea that plaques producing non-flow-limiting stenoses account for more cases of plaque rupture and thrombosis than plaques producing a more severe stenosis. Due to this fact, plaque itself must be imaged in order to assess its vulnerability. A wealth of literature suggests that multicontrast MRI has the potential of characterizing plaque constituents, and thus is a promising technique for plaque imaging. Because of the technical difficulties associated with in-vivo plaque imaging and the fact that our research was aimed at developing new methodologies, our approaches was to image excised coronary arteries under simulated in-vivo conditions in a tissue culture chamber. It is shown by this research that automatic plaque characterization techniques developed under ex-vivo conditions still apply for in-vivo studies. Based on this finding, an automatic plaque characterization technique using multicontrast MRI was developed. Furthermore, "shared k-space" reconstruction techniques were interrogated to assess their feasibility in accelerating multicontrast MRI acquisition. Results show that these techniques are promising in accelerating multicontrast MRI acquisitions. en_US
dc.description.degree Ph.D. en_US
dc.identifier.uri http://hdl.handle.net/1853/16291
dc.publisher Georgia Institute of Technology en_US
dc.subject Atherosclerosis en_US
dc.subject MRI en_US
dc.subject Plaque characterization en_US
dc.subject.lcsh Atherosclerotic plaque Magnetic resonance imaging en_US
dc.title Multicontrast MRI of Atherosclerotic Plaques: Acquisition, Characterization and Reconstruction en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Oshinski, John N.
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 05472fe1-6d57-4489-af83-42115a3f55cc
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
sun_binjian_200708_phd.pdf
Size:
2.73 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Theses and Dissertations