Title:
Simulations of pulsatile flow through bileaflet mechanical heart valves using a suspension flow model: to assess blood damage

dc.contributor.advisor Yoganathan, Ajit P.
dc.contributor.advisor Aidun, Cyrus K.
dc.contributor.author Yun, Brian Min
dc.contributor.committeeMember Neitzel, Paul
dc.contributor.committeeMember Taylor, Robert
dc.contributor.committeeMember Giddens, Don P.
dc.contributor.department Mechanical Engineering
dc.date.accessioned 2015-06-08T17:59:32Z
dc.date.available 2015-06-09T05:30:06Z
dc.date.created 2014-05
dc.date.issued 2013-12-18
dc.date.submitted May 2014
dc.date.updated 2015-06-08T17:59:32Z
dc.description.abstract Defective or diseased native valves have been replaced by bileaflet mechanical heart valves (BMHVs) for many years. However, severe complications still exist, and thus blood damage that occurs in BMHV flows must be well understood. The aim of this research is to numerically study platelet damage that occurs in BMHV flows. The numerical suspension flow method combines lattice-Boltzmann fluid modeling with the external boundary force method. This method is validated as a general suspension flow solver, and then validated against experimental BMHV flow data. Blood damage is evaluated for a physiologic adult case of BMHV flow and then for BMHVs with pediatric sizing and flow conditions. Simulations reveal intricate, small-scale BMHV flow features, and the presence of turbulence in BMHV flow. The results suggest a shift from previous evaluations of instantaneous flow to the determination of long-term flow recirculation regions when assessing thromboembolic potential. Sharp geometries that may induce these recirculation regions should be avoided in device design. Simulations for predictive assessment of pediatric sized valves show increased platelet damage values for potential pediatric valves. However, damage values do not exceed platelet activation thresholds, and highly damaged platelets are found far from the valve. Thus, the increased damage associated with resized valves is not such that pediatric valve development should be hindered. This method can also be used as a generic tool for future evaluation of novel prosthetic devices or cardiovascular flow problems.
dc.description.degree Ph.D.
dc.embargo.terms 2015-05-01
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/53378
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Biomedical flows
dc.subject Prosthetic devices
dc.subject Cardiovascular flows
dc.subject Blood damage
dc.subject Lattice-Boltzmann methods
dc.subject Computational fluid dynamics
dc.subject Vorticity dynamics
dc.subject Suspension flows
dc.subject Computational methods
dc.subject High performance computing
dc.title Simulations of pulsatile flow through bileaflet mechanical heart valves using a suspension flow model: to assess blood damage
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Aidun, Cyrus K.
local.contributor.advisor Yoganathan, Ajit P.
local.contributor.corporatename George W. Woodruff School of Mechanical Engineering
local.contributor.corporatename College of Engineering
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relation.isAdvisorOfPublication 6a910742-4bed-4ba6-b03d-f92e4c915a00
relation.isOrgUnitOfPublication c01ff908-c25f-439b-bf10-a074ed886bb7
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level Doctoral
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