Title:
Single Cell Analysis of Patients with Perianal Chron’s Disease
Single Cell Analysis of Patients with Perianal Chron’s Disease
| dc.contributor.advisor | Goodisman, Michael | |
| dc.contributor.author | Ferguson, Katherine Elizabeth | |
| dc.contributor.committeeMember | Gibsom, Greg | |
| dc.contributor.department | Biology | |
| dc.contributor.department | Biology | |
| dc.date.accessioned | 2020-11-09T17:00:06Z | |
| dc.date.available | 2020-11-09T17:00:06Z | |
| dc.date.created | 2020-05 | |
| dc.date.issued | 2020-05 | |
| dc.date.submitted | May 2020 | |
| dc.date.updated | 2020-11-09T17:00:07Z | |
| dc.description.abstract | Perianal Chron’s Disease is a debilitating form of Chron’s Disease that often involves rectal tissue in its manifestation in the body. There is a greater need for understanding of the role of the epithelial tissue in the rectum in the pathology of Chron’s Disease. This study aims to determine cellular make-up of rectal-derived organoids grown from Chron’s Disease patients. Through the use of single-cell transcriptomics, this study will determine the cell types present in four rectal-derived organoids and use differential expression to analyze differences in epithelial tissue of Chron’s Disease patients in comparison to a healthy individual. | |
| dc.description.degree | Undergraduate | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/1853/63885 | |
| dc.language.iso | en_US | |
| dc.publisher | Georgia Institute of Technology | |
| dc.subject | Chron's Disease | |
| dc.subject | Organoid | |
| dc.subject | ScRNA seq | |
| dc.subject | Single Cell | |
| dc.title | Single Cell Analysis of Patients with Perianal Chron’s Disease | |
| dc.type | Text | |
| dc.type.genre | Undergraduate Thesis | |
| dspace.entity.type | Publication | |
| local.contributor.advisor | Goodisman, Michael | |
| local.contributor.corporatename | College of Sciences | |
| local.contributor.corporatename | School of Biological Sciences | |
| local.contributor.corporatename | Undergraduate Research Opportunities Program | |
| local.relation.ispartofseries | Undergraduate Research Option Theses | |
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| thesis.degree.level | Undergraduate |