Title:
Single Cell Analysis of Patients with Perianal Chron’s Disease
Single Cell Analysis of Patients with Perianal Chron’s Disease
Author(s)
Ferguson, Katherine Elizabeth
Advisor(s)
Goodisman, Michael
Editor(s)
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Abstract
Perianal Chron’s Disease is a debilitating form of Chron’s Disease that often involves rectal tissue in its manifestation in the body. There is a greater need for understanding of the role of the epithelial tissue in the rectum in the pathology of Chron’s Disease. This study aims to determine cellular make-up of rectal-derived organoids grown from Chron’s Disease patients. Through the use of single-cell transcriptomics, this study will determine the cell types present in four rectal-derived organoids and use differential expression to analyze differences in epithelial tissue of Chron’s Disease patients in comparison to a healthy individual.
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Date Issued
2020-05
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Resource Type
Text
Resource Subtype
Undergraduate Thesis