Title:
Mechanical Characterization of Tricuspid Bicuspidization in a Porcine Model
Mechanical Characterization of Tricuspid Bicuspidization in a Porcine Model
| dc.contributor.author | Pataky, Joshua | |
| dc.contributor.committeeMember | Sun, Wei | |
| dc.contributor.committeeMember | Sun, Wei | |
| dc.contributor.department | Biomedical Engineering (Joint GT/Emory Department) | |
| dc.date.accessioned | 2019-05-30T16:23:47Z | |
| dc.date.available | 2019-05-30T16:23:47Z | |
| dc.date.created | 2019-05 | |
| dc.date.issued | 2019-05 | |
| dc.date.submitted | May 2019 | |
| dc.date.updated | 2019-05-30T16:23:47Z | |
| dc.description.abstract | Tricuspid valve regurgitation currently affects over 1.6 million people in the US and largely uses annuloplasty ring deployment as the main method of correction for severe regurgitation. As this method inherently contains a number of risks, among others, the Kay bicuspidization procedure has been adapted for use as a transcatheter device. This procedure places anchors in the valve annulus on either side of the posterior leaflet and cinches them together, creating a bicuspid valve. The mechanics involved in this bicuspidization process, however, are poorly understood; this study looks to quantify those mechanics. Paired healthy and regurgitant porcine hearts were attached to a custom chamber, with regurgitation being induced through the topical application of 95% phenol. Tricuspid valve annular area, diastolic leakage, cinching tension, and annulus ellipticity are quantified at different cinching distances. As predicted, the use of phenol to induce tricuspid regurgitation is seen to be effective. The bicuspidization cinching reduces annular area and diastolic leakage in diseased case hearts to that of a “healthy” heart through altering the annulus geometry towards a more circular shape. | |
| dc.description.degree | Undergraduate | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/1853/61374 | |
| dc.language.iso | en_US | |
| dc.publisher | Georgia Institute of Technology | |
| dc.subject | Cardiovascular disease | |
| dc.subject | Tricuspid regurgitation | |
| dc.subject | Bicuspidization | |
| dc.title | Mechanical Characterization of Tricuspid Bicuspidization in a Porcine Model | |
| dc.type | Text | |
| dc.type.genre | Undergraduate Thesis | |
| dspace.entity.type | Publication | |
| local.contributor.corporatename | Wallace H. Coulter Department of Biomedical Engineering | |
| local.contributor.corporatename | Undergraduate Research Opportunities Program | |
| local.contributor.corporatename | College of Engineering | |
| local.relation.ispartofseries | Undergraduate Research Option Theses | |
| relation.isOrgUnitOfPublication | da59be3c-3d0a-41da-91b9-ebe2ecc83b66 | |
| relation.isOrgUnitOfPublication | 0db885f5-939b-4de1-807b-f2ec73714200 | |
| relation.isOrgUnitOfPublication | 7c022d60-21d5-497c-b552-95e489a06569 | |
| relation.isSeriesOfPublication | e1a827bd-cf25-4b83-ba24-70848b7036ac | |
| thesis.degree.level | Undergraduate |