Title:
Poly(para-phenyleneethynylene)s: probing the biological interface with biomolecular materials
Poly(para-phenyleneethynylene)s: probing the biological interface with biomolecular materials
Author(s)
Phillips, Ronald Lee, III
Advisor(s)
Bunz, Uwe H. F.
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Abstract
The synthesis and biological sensing applications of novel water soluble poly(para-phenyleneethynylene)s (PPEs) are presented. The ease of synthesis, synthetic variability, and dramatic chromicity of PPEs makes them well suited for biological and sensing applications. Molecular recognition and signal transduction can be achieved by using PPEs as sensory materials. By incorporating biological functional groups (e.g. sugars), PPEs can efficiently detect the presence of toxic heavy metals, proteins, and bacteria through either fluorescence quenching or enhancement. Rapid, precise, and convenient sensory arrays for the detection of biological analytes are possible through the formation of gold nanoparticle-PPE constructs.
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Date Issued
2008-08-20
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Resource Type
Text
Resource Subtype
Dissertation