Title:
Optimizing solvent selection for separation and reaction

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dc.contributor.advisor Eckert, Charles A.
dc.contributor.advisor Liotta, Charles L.
dc.contributor.author Lazzaroni, Michael John en_US
dc.contributor.committeeMember Teja, Amyn S.
dc.contributor.committeeMember Meredith, J. Carson
dc.contributor.committeeMember Rigoberto Hernandez
dc.contributor.department Chemical Engineering en_US
dc.date.accessioned 2005-03-02T22:37:02Z
dc.date.available 2005-03-02T22:37:02Z
dc.date.issued 2004-07-12 en_US
dc.description.abstract Solvent selection is an important factor in chemical process efficiency, profitability, and environmental impact. Prediction of solvent phase behavior will allow for the identification of novel solvent systems that could offer some economic or environmental advantage. A modified cohesive energy density model is used to predict the solid-liquid-equilibria for multifunctional solids in pure and mixed solvents for rapid identification of process solvents for design of crystallization processes. Some solubility data at several temperatures are also measured to further test the general applicability of the model. Gas-expanded liquids have potential environmentally advantageous applications as pressure tunable solvents for homogeneous and heterogeneous catalytic reactions and as novel solvent media for anti-solvent crystallizations. The phase behavior of some carbon dioxide/organic binary systems is measured to provide basic process design information. Solvent selection is also an important factor in the anti-solvent precipitation of solid compounds. The influence of organic solvent on the solid-liquid equilibria for two solid pharmaceutical compounds in several carbon dioxide expanded solvents is explored. A novel solvent system is also developed that allows for homogeneous catalytic reaction and subsequent catalyst sequestration by using carbon dioxide as a miscibility switch. The fundamental biphasic solution behavior of some polar organics with water and carbon dioxide are investigated. en_US
dc.description.degree Ph.D. en_US
dc.format.extent 5957712 bytes
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/5080
dc.language.iso en_US
dc.publisher Georgia Institute of Technology en_US
dc.subject Gas-expanded liquids en_US
dc.subject High pressure phase equilibria
dc.subject Solid solubility
dc.title Optimizing solvent selection for separation and reaction en_US
dc.type Text
dc.type.genre Thesis
dspace.entity.type Publication
local.contributor.advisor Eckert, Charles A.
local.contributor.advisor Liotta, Charles L.
local.contributor.corporatename School of Chemical and Biomolecular Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 4b9f2e38-c211-4513-bc14-84855881983c
relation.isAdvisorOfPublication 70381731-0633-4be9-8756-42fbf84ac767
relation.isOrgUnitOfPublication 6cfa2dc6-c5bf-4f6b-99a2-57105d8f7a6f
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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