Title:
Nematodes adapt using yin-yang isoforms of a NURF subunit
Nematodes adapt using yin-yang isoforms of a NURF subunit
| dc.contributor.advisor | McGrath, Patrick T. | |
| dc.contributor.author | Xu, Wen | |
| dc.contributor.committeeMember | Streelman, Jeffery T. | |
| dc.contributor.committeeMember | Gibson, Greg | |
| dc.contributor.committeeMember | Katz, David J. | |
| dc.contributor.committeeMember | Paaby, Annalise | |
| dc.contributor.department | Biology | |
| dc.date.accessioned | 2019-05-29T14:03:04Z | |
| dc.date.available | 2019-05-29T14:03:04Z | |
| dc.date.created | 2019-05 | |
| dc.date.issued | 2019-04-02 | |
| dc.date.submitted | May 2019 | |
| dc.date.updated | 2019-05-29T14:03:04Z | |
| dc.description.abstract | Convergent or parallel evolution is the repeated evolution of the same genotype in independent populations in response to similar environmental changes. A growing number of examples of parallel evolution are accumulating in the literature (e.g. cis-regulatory changes in the shavenbaby developmental regulator in Drosophila species result in dorsal cuticle hair loss [1], repeated selection on the Eda TNF ligand causes stickleback low-plated phenotype [2], and deletion of chemoreceptor genes contribute to the insensitivity to a specific pheromone in Caenorhabditis species [3]). In this dissertation, I discussed my studies of how Caenorhabditis elegans strains adapt to laboratory environments. I described how two C. elegans strains N2 and LSJ2, who share a common ancestor but have evolved independently in laboratory conditions have increased fitness in their respective environment. I showed that part of adaptation in the LSJ2 strain is caused by a 60 bp deletion in nurf-1 gene, a subunit of nucleosome remodeling factor NURF. Next, I described my finding about that adaptation of the N2 lineage is partially caused by a SNV (single nucleotide variation) in the 2nd intron of nurf-1. This work suggests that nurf-1 is a common target of evolution in response to laboratory growth. Finally, I described my work to understand why nurf-1 might be targeted, which I propose is due to the antagonistic function (here I refer as Yin-yang) of two major nurf-1 isoforms on the sexual fate during gametogenesis. My doctoral thesis study advances our understanding of how nucleosome remodeling factor may work and that isoform-level study of complex genes is feasible and necessary. | |
| dc.description.degree | Ph.D. | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/1853/61251 | |
| dc.language.iso | en_US | |
| dc.publisher | Georgia Institute of Technology | |
| dc.subject | Nurf-1 | |
| dc.subject | Evolutionary hotspot | |
| dc.subject | Antagonistic isoforms | |
| dc.title | Nematodes adapt using yin-yang isoforms of a NURF subunit | |
| dc.type | Text | |
| dc.type.genre | Dissertation | |
| dspace.entity.type | Publication | |
| local.contributor.advisor | McGrath, Patrick T. | |
| local.contributor.corporatename | College of Sciences | |
| local.contributor.corporatename | School of Biological Sciences | |
| relation.isAdvisorOfPublication | e7f5ac4a-60c4-48e8-81a3-3e0d225ff44a | |
| relation.isOrgUnitOfPublication | 85042be6-2d68-4e07-b384-e1f908fae48a | |
| relation.isOrgUnitOfPublication | c8b3bd08-9989-40d3-afe3-e0ad8d5c72b5 | |
| thesis.degree.level | Doctoral |