Morphology Change of Optic Nerve Sheath (ONS) in Idiopathic Intracranial Hypertension (IIH) Patients (Pre- and Post-CSF Drainage)

dc.contributor.author Kim, Chan Su
dc.contributor.committeeMember Oshinski, John N.
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2017-07-28T18:33:40Z
dc.date.available 2017-07-28T18:33:40Z
dc.date.created 2017-05
dc.date.issued 2017-05
dc.date.submitted May 2017
dc.date.updated 2017-07-28T18:33:40Z
dc.description.abstract Idiopathic Intracranial Hypertension (IIH) is a neurological disorder which can cause the irreversible vision loss due to increased pressure in intracranial space. High pressure in intracranial space expands the optic nerve sheath (ONS), therefore, the optic nerve (ON) gets out of its shape, which triggers the optic nerve twist and globe flattening. Because the elevation of pressure is scientifically unknown, many studies have been conducted to find the root of pressure increase. Meanwhile, none of the previous studies have analyzed the optic nerve sheath diameter (ONSD) change and cerebral spinal fluid (CSF) volume change between pre-CSF drainage vs. post-CSF drainage. This study used T-2 weighted magnetic resonance (MR) imaging techniques to quantitatively measure the ONSD, and compared the ONSD between pre- and post-lumbar puncture procedure. 75% of regions of interest (ROI) which are selected along the optic nerve showed that CSF area and ONSD decreased after the lumbar puncture procedure. Statistical significant difference was found at 11mm anterior to the vitreoretinal interface. In addition, the difference in volume after the lumbar puncture procedure was 2.7mm3.
dc.description.degree Undergraduate
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/58496
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Idiopathic Intracranial Hypertension
dc.subject IIH
dc.subject Optic nerve
dc.subject ON
dc.subject Optic nerve sheath
dc.subject ONS
dc.subject ONSD
dc.subject Optic nerve sheath diameter
dc.subject Lumbar puncture
dc.title Morphology Change of Optic Nerve Sheath (ONS) in Idiopathic Intracranial Hypertension (IIH) Patients (Pre- and Post-CSF Drainage)
dc.type Text
dc.type.genre Undergraduate Thesis
dspace.entity.type Publication
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename Undergraduate Research Opportunities Program
local.contributor.corporatename College of Engineering
local.relation.ispartofseries Undergraduate Research Option Theses
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 0db885f5-939b-4de1-807b-f2ec73714200
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
relation.isSeriesOfPublication e1a827bd-cf25-4b83-ba24-70848b7036ac
thesis.degree.level Undergraduate
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
755.63 KB
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
3.86 KB
Plain Text