Glial Fibrillary Acidic Protein (GFAP) Response in a Preclinical Rat Model of mTBI Glial Fibrillary Acidic Protein (GFAP) Response in a Preclinical Rat Model of mTBI

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HEYDARI-UNDERGRADUATERESEARCHOPTIONTHESIS-2021.pdf (909.35 KB)
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Heydari, Tara
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Wallace H. Coulter Department of Biomedical Engineering
The joint Georgia Tech and Emory department was established in 1997
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http://hdl.handle.net/1853/64877
Abstract
Traumatic brain injury (TBI) impairs populations both physically and financially, explaining about 75% of all head injuries and costing over $60 billion in the United States (Ahmed et.al, 2015 and Maas et. al, 2010). Through histopathological techniques and imaging, we measured the GFAP response to mild traumatic brain injury (mTBI) in a preclinical rat model using a heterogenous experimental design to mimic the heterogeneity in the human population as closely as possible. Using an ANOVA statistical analysis, the variance between the average astrocytic area in each group will be assessed for significance with respective post-hoc analyses to follow. Due to the lab closings of COVID-19, the results and statistical analyses have not been conducted, although all the data has been collected and measured. The significance of this translational neurotrauma study lies in its aforementioned heterogenous research design to build upon the foundation for the bridge between the laboratory and the clinical settings.
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2021-05
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Undergraduate Thesis
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