Title:
Mir-200 Family Induces Mesenchymal-to-epithelial Transition (met) In Ovarian Cancer Cells

dc.contributor.patentcreator Mcdonald, John
dc.contributor.patentcreator Bowen, Nathan John
dc.contributor.patentcreator Wang, Lijuan
dc.date.accessioned 2017-05-12T14:26:31Z
dc.date.available 2017-05-12T14:26:31Z
dc.date.filed 11/23/2011
dc.date.issued 11/25/2014
dc.description.abstract The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to treat the ovarian cancer. Also provided are methods of preventing metastasis of an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to prevent metastasis. Further provided are methods of sensitizing an ovarian cancer to a cytotoxic therapy, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to sensitize the ovarian cancer to the cytotoxic therapy. The invention also contemplates methods of reducing epithelial-to-mesenchymal transition (EMT) in an ovarian cancer or cancer cell as well as methods of inducing mesenchymal-to-epithelial transition (MET).
dc.description.assignee Georgia Tech Research Corporation
dc.identifier.cpc A61K9/00
dc.identifier.cpc A61K31/713
dc.identifier.cpc C12N15/113
dc.identifier.patentapplicationnumber 13/989312
dc.identifier.patentnumber 8895509
dc.identifier.uri http://hdl.handle.net/1853/56945
dc.identifier.uspc 514/19.3
dc.title Mir-200 Family Induces Mesenchymal-to-epithelial Transition (met) In Ovarian Cancer Cells
dc.type Text
dc.type.genre Patent
dspace.entity.type Publication
local.contributor.corporatename Georgia Institute of Technology
local.relation.ispartofseries Georgia Tech Patents
relation.isOrgUnitOfPublication cc30e153-7a64-4ae2-9b1d-5436686785e3
relation.isSeriesOfPublication 0f49c79d-4efb-4bd9-b060-5c7f9191b9da
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