EFFECT OF GEOMETRY, RESPIRATION AND VESSEL DEFORMABILITY ON FONTAN HEMODYNAMICS: A NUMERICAL INVESTIGATION

Tang, Tsz Ling Elaine

Title:

EFFECT OF GEOMETRY, RESPIRATION AND VESSEL DEFORMABILITY ON FONTAN HEMODYNAMICS: A NUMERICAL INVESTIGATION

dc.contributor.advisor	Yoganathan, Ajit P.
dc.contributor.author	Tang, Tsz Ling Elaine
dc.contributor.committeeMember	del Nido, Pedro J
dc.contributor.committeeMember	Veneziani, Alessandro
dc.contributor.committeeMember	McElhinney, Doff B
dc.contributor.committeeMember	Lu, Hang
dc.contributor.committeeMember	Sambanis, Athanassios
dc.contributor.department	Chemical and Biomolecular Engineering
dc.date.accessioned	2017-01-11T13:59:56Z
dc.date.available	2017-01-11T13:59:56Z
dc.date.created	2015-12
dc.date.issued	2015-11-17
dc.date.submitted	December 2015
dc.date.updated	2017-01-11T13:59:56Z
dc.description.abstract	Single ventricle (SV) congenital heart defects occur in 2 of every 1000 live births in the US. The Fontan procedure, the common palliation of single ventricle heart defect patients, results in the bypass the right ventricle, completing the total cavopulmonary connection (TCPC). Even though this procedure results in favorable short-term outcomes, Fontan patients are subjected to a series of long-term complications, including reduced exercise capacity and life expectancy. The exact causes of these long-term complications are not clear, but some are attributed to the unfavorable hemodynamics in the TCPC. In this thesis, the impact of geometry, respiration-driven flow, and vessel wall deformability on TCPC hemodynamics was evaluated and compared. First, the impact of patient specific geometry was studied by characterizing the patient specific anatomic features of a large patient cohort of TCPCs obtained from cardiac magnetic resonance (CMR) images. Second, the influence of respiratory-driven flow was investigated by comparing TCPC hemodynamics simulated using a vessel flow waveform obtained from both free-breathing and breath-held phase-contrast CMR acquisitions. Third, the effect of wall deformability was studied by comparing TCPC hemodynamics under rigid wall and compliant wall conditions. At the end of this thesis, the impact of patient specific geometry, flow pulsatility, respiration, and wall compliance on TCPC hemodynamics was discussed.
dc.description.degree	Ph.D.
dc.format.mimetype	application/pdf
dc.identifier.uri	http://hdl.handle.net/1853/56206
dc.language.iso	en_US
dc.publisher	Georgia Institute of Technology
dc.subject	Congenital heart disease
dc.subject	Fluid mechanics
dc.subject	Computational fluid dynamics
dc.subject	Pediatric cardiology
dc.title	EFFECT OF GEOMETRY, RESPIRATION AND VESSEL DEFORMABILITY ON FONTAN HEMODYNAMICS: A NUMERICAL INVESTIGATION
dc.type	Text
dc.type.genre	Dissertation
dspace.entity.type	Publication
local.contributor.advisor	Yoganathan, Ajit P.
local.contributor.corporatename	School of Chemical and Biomolecular Engineering
local.contributor.corporatename	College of Engineering
relation.isAdvisorOfPublication	6a910742-4bed-4ba6-b03d-f92e4c915a00
relation.isOrgUnitOfPublication	6cfa2dc6-c5bf-4f6b-99a2-57105d8f7a6f
relation.isOrgUnitOfPublication	7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level	Doctoral