Title:
New Methods of Retinal Delivery for Treating Neurodegenerative Eye Diseases
New Methods of Retinal Delivery for Treating Neurodegenerative Eye Diseases
Author(s)
Hejri Bidgoli, Amir
Advisor(s)
Prausnitz, Mark R.
Editor(s)
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Abstract
Novel therapeutics have emerged for treating neurodegenerative eye diseases but are limited by
suboptimal methods of retinal administration. In this work, we strived to improve retinal delivery
by 1) developing a simple and minimally invasive drug administration method using microneedle
technology, and 2) studying the biomechanics of the subretinal space of the eye to better control
and enhance biodistribution of injected materials. In doing so, we developed a microneedle-based
injection technique that enabled controlled penetration into ocular tissues, i.e., subretinal and
suprachoroidal space, with high degree of precision and minimal tissue damage. Furthermore, by
detailed study of the mechanics of fluid-tissue interactions in the subretinal space, we discovered
a new mechanism of subretinal delivery involving flow instability-driven bifurcation pattern
formation which has not been reported before in the eye or any other biological tissue. This new
understanding provided a strategy for suppression of unsafe blister formation and increased
biodistribution of injection.
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Date Issued
2022-07-30
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Resource Type
Text
Resource Subtype
Dissertation