OSTEMER Microfluidic Device Fabrication Method
Author(s)
Sultan, Maya
Advisor(s)
Editor(s)
Collections
Supplementary to:
Permanent Link
Abstract
The primary goal of this research project is to develop a cost-effective fabrication method for rigid microfluidic devices in order to enable high-pressure flow. Research activities include the testing of various chemical treatments to improve device biocompatibility, alongside the conducting of a microfluidic experiment with cell lines to test cell-channel interaction and assay post treatment cell viability. If assay development on the OSTEMER-devices determines that cells are not biocompatible, chemical passivation methods and buffer additives can be applied to reduce adhesion within the devices. Assay development on jurkat and human peripheral blood mononuclear cells (PBMC) produced cell viability results that proved OSTEMER is a viable material for microfluidic device fabrication, with injected cells maintaining high viability under various levels of high-pressure flow.
Sponsor
Date
Extent
Resource Type
Text
Resource Subtype
Undergraduate Research Option Thesis