Interdisciplinary Investigations into Sensory Neuron Mechanisms and Modulations in Health and Disease
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Nho, Yeseul
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Abstract
The somatosensory system is a critical component to maintaining homeostasis and is often one of the first responders to changes in external and internal stimuli, quickly triggering the body to mitigate any threats. However, despite continuous and significant advancements in our understanding of the somatosensory system’s role in various facets of health and disease from skin disease to non-invasive technologies for sensory neuron manipulation, many of the complex mechanisms still remain widely unknown, which hinders novel and effective treatments that may reduce economic and health burdens. In this dissertation, I attempt to answer some of these critical questions that remain unanswered by (1) investigating toxins released by S. aureus, which may be implicated in atopic dermatitis (AD), (2) conducting a function analysis of Mas-related G protein-coupled receptor (Mrgpr) C11+ neurons within the vagal ganglia (VG) that innervate and contribute to the function of the airway, and (3) revealing ultrasound parameters that may be critical to FUS-induced neuromodulation. These findings reveal new avenues for research in a wide range of areas involving the somatosensory system, may provide novel tools for studying the role of the somatosensory system in facets of health and disease, and offer crucial insights for future therapeutic efforts.
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2024-04-24
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Dissertation