Title:
Development and Validation of a Nanodosimetry-Based Cell Survival Model for Mixed High- and Low-LET radiations

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dc.contributor.advisor Wang, C.-K. Chris
dc.contributor.author Zhang, Xin en_US
dc.contributor.committeeMember Al-Sheikhly,Mohamad
dc.contributor.committeeMember Hertel, Nolan
dc.contributor.committeeMember Radhakrishna,Harish
dc.contributor.committeeMember Rahnema,Farzad
dc.contributor.department Mechanical Engineering en_US
dc.date.accessioned 2006-09-01T19:29:47Z
dc.date.available 2006-09-01T19:29:47Z
dc.date.issued 2006-06-13 en_US
dc.description.abstract A new nanodosimetry-based cell survival model for mixed high- and low-LET radiations has been developed. The new model employs three dosimetry quantities and three biological quantities. The three dosimetry quantities are related to energy depositions at two nanometer scales, 5nm and 25nm. The three biological quantities are related to lesion production and interaction probabilities, and lesion repair rate. The model assumes that the lesions created at the two nanometer scales are directly or indirectly responsible for cell death depending on the lesions interaction and repair rate. The cell survival fraction derived from the new model can be expressed by the familiar dose-dependent linear quadratic formula. The coefficients alpha and beta are based on the three nanodosimetry quantities and the three biological quantities. Validation of the new model has been performed both by using published data and by the experimental data obtained. Published cell survival curves for V-79 Chinese hamster cells irradiated with various LET of radiations were used for validation. The new model was applied to radiation therapy by irradiating V-79 cells with mixed fission neutron and gamma-rays. The results show that the new model has been successfully used in a mixed n+g field to predict the synergistic effect between neutron and gamma-ray lesions and the RBE for fission neutrons. en_US
dc.description.degree Ph.D. en_US
dc.format.extent 1227760 bytes
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/11523
dc.language.iso en_US
dc.publisher Georgia Institute of Technology en_US
dc.subject Cell survival model en_US
dc.subject V-79 cell survival curves
dc.subject Fission neutron irradiation
dc.subject.lcsh Cells Effect of radiation on Mathematical models en_US
dc.title Development and Validation of a Nanodosimetry-Based Cell Survival Model for Mixed High- and Low-LET radiations en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Wang, C.-K. Chris
local.contributor.corporatename George W. Woodruff School of Mechanical Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 71d23899-d6d4-4d7f-b9bc-d30323a6f442
relation.isOrgUnitOfPublication c01ff908-c25f-439b-bf10-a074ed886bb7
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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