Title:
A hierarchical approach to the prediction of the quaternary structure of GCN4 and its mutants
A hierarchical approach to the prediction of the quaternary structure of GCN4 and its mutants
| dc.contributor.author | Vieth, Michal | |
| dc.contributor.author | Kolinski, Andrzej | |
| dc.contributor.author | Brooks, C. L., III | |
| dc.contributor.author | Skolnick, Jeffrey | |
| dc.contributor.corporatename | Scripps Research Institute | |
| dc.date.accessioned | 2009-05-14T14:20:06Z | |
| dc.date.available | 2009-05-14T14:20:06Z | |
| dc.date.issued | 1996 | |
| dc.description | First published in DIMACS Series in Discrete Mathematics and Theoretical Computer Science, 23 (1996) published by the American Mathematical Society. | en |
| dc.description | Presented at DIMACS Workshop on Global Minimization of Nonconvex Energy Functions: Molecular Conformation and Protein Folding, March 20-21, 1995. | |
| dc.description.abstract | A hierarchical approach to protein folding is employed to examine the folding pathway and predict the quaternary structure of the GCN4 leucine zipper. Structures comparable in quality to experiment have been predicted. In addition, the equilibrium between dimers, trimers and tetramers of a number of GCN4 mutants has been examined. In five out of eight cases, the simulation results are in accordance with the experimental studies of Harbury, et al. | en |
| dc.identifier.citation | DIMACS Series in Discrete Mathematics and Theoretical Computer Science, 23 (1996) 233-236 | en |
| dc.identifier.issn | 1052-1798 | |
| dc.identifier.uri | http://hdl.handle.net/1853/27922 | |
| dc.language.iso | en_US | en |
| dc.publisher | Georgia Institute of Technology | en |
| dc.publisher.original | American Mathematical Society | |
| dc.subject | Protein folding | en |
| dc.subject | GCN4 leucine zipper | en |
| dc.subject | Computer simulations | en |
| dc.subject | Lattice protein models | en |
| dc.title | A hierarchical approach to the prediction of the quaternary structure of GCN4 and its mutants | en |
| dc.type | Text | |
| dc.type.genre | Proceedings | |
| dspace.entity.type | Publication | |
| local.contributor.author | Skolnick, Jeffrey | |
| local.contributor.corporatename | College of Sciences | |
| local.contributor.corporatename | School of Biological Sciences | |
| local.contributor.corporatename | Center for the Study of Systems Biology | |
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