Title:
A hierarchical approach to the prediction of the quaternary structure of GCN4 and its mutants
A hierarchical approach to the prediction of the quaternary structure of GCN4 and its mutants
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Author(s)
Vieth, Michal
Kolinski, Andrzej
Brooks, C. L., III
Skolnick, Jeffrey
Kolinski, Andrzej
Brooks, C. L., III
Skolnick, Jeffrey
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Abstract
A hierarchical approach to protein folding is employed to examine the folding pathway and predict the quaternary structure of the GCN4 leucine zipper. Structures comparable in quality to experiment have been predicted. In addition, the equilibrium between dimers, trimers and tetramers of a number of GCN4 mutants has been examined. In five out of eight cases, the simulation results are in accordance with the experimental studies of Harbury, et al.
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Date Issued
1996
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Proceedings