Title:
Green and effective continuous multi-step synthesis of ring-fused heteroaromatics

dc.contributor.author Liotta, Charles L.
dc.contributor.author Eckert, Charles A.
dc.contributor.author France, Stefan
dc.contributor.author Pollet, Pamela
dc.contributor.corporatename Georgia Institute of Technology. Office of Sponsored Programs en_US
dc.contributor.corporatename Georgia Institute of Technology. School of Chemistry and Biochemistry en_US
dc.date.accessioned 2016-10-21T19:16:29Z
dc.date.available 2016-10-21T19:16:29Z
dc.date.issued 2013
dc.description Issued as final report en_US
dc.description.abstract Historically, batch processing has been the major strategy in the synthesis of complex molecules, especially molecules of pharmaceutical interest. In general, this approach has been fraught with high cost, excessive time for scale-up, and waste issues. In order to address these issues, continuous flow technology has been identified as an alternative production vehicle since it has both environmental and economic advantages. Continuous flow technology offers superior mass and heat transfer, and lower production costs when compared with the traditional batch technology. Technological transfer from batch to continuous flow maximizes performance in terms of product yield and selectivity while minimizing solvent and catalyst needs thereby lowering production costs. In addition, continuous flow processes can be “scaled out” in contrast to batch processes that must be “scaled up.” In this research project, we take advantage of continuous flow technology to conduct the multi-step synthesis shown in Scheme 1. en_US
dc.description.sponsorship American Chemical Society en_US
dc.identifier.uri http://hdl.handle.net/1853/55964
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.relation.ispartofseries School of Chemistry and Biochemistry ; Project no. 118774 en_US
dc.subject Continuous flow en_US
dc.title Green and effective continuous multi-step synthesis of ring-fused heteroaromatics en_US
dc.type Text
dc.type.genre Technical Report
dspace.entity.type Publication
local.contributor.author Eckert, Charles A.
local.contributor.author France, Stefan
local.contributor.author Liotta, Charles L.
local.contributor.corporatename School of Chemistry and Biochemistry
local.contributor.corporatename College of Sciences
local.contributor.corporatename Office of Sponsored Programs
local.relation.ispartofseries OSP Final Research Reports
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