Design of Microelectrode Arrays for The Dnaorigami Orientation Control and the Long-Term Stable Measurement of Bacteria
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Lee, Dongwon
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Abstract
Microelectrode arrays (MEAs) have great potential in a variety of emerging
applications, including brain-machine interfaces (BMIs), point-of-care (PoC) devices, in
vitro drug screening, molecular sensing, and bio-microelectromechanical systems
(bioMEMs). Also, electrical signals can be delivered through MEAs to stimulate cells and
manipulate molecules.
DNA origami is one of the promising technology for nanoelectronics and nano-optical
devices. The performance of nano-optical devices depends on the precise position and
orientation of optical components. To resolve this challenge, the method to control DNA
origami orientation through Dielectrophoresis (DEP) will be discussed.
Achieving high-resolution analysis with electrochemical sensing modalities
necessitates the use of microelectrode arrays (MEAs). Ag/AgCl quasi-reference electrodes
integrated with MEAs have been shown in many studies. To fabricate on-chip Ag/AgCl quasi reference
electrodes, electrochemically deposition and printing have been utilized.
However, these methods are not scalable and require unnecessary circuitry for
complementary metal-oxide-semiconductor (CMOS) chips, respectively. Moreover, for
long-term measurement of living cells, the biocompatible coating is needed for Ag/AgCl
quasi-reference electrode. Here, highly miniaturized, scalable Ag/AgCl quasi-reference
electrodes with long-term stable open-circuit voltage (OCV) and biocompatibility will be
provided.
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Date
2022-08-02
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