Synthesis and Applications of Complex Microparticles Using Microfluidic Devices
Author(s)
Doyle, Patrick S.
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Abstract
Microfluidic devices offer the ability to finely control physical and chemical conditions
which is advantageous for materials synthesis. Several groups have used multi-phase
microflows to produce microparticles and capsules. Surface tension limits these
particles to be spheroids. In this talk we will introduce a new technique entitled Stop
Flow Lithography (SFL) which couples microfluidics and projection lithography to
create microparticles with unprecedented chemical and geometric complexity. We will
first demonstrate the versatility of SFL by showing how it can be used to create
materials ranging from soft cell-laden microgel blocks for applications in tissue
engineering to ceramic microcomponents for MEMs to TMV virus-patterned particles.
Next we will discuss a specific application of SFL to create barcoded microparticles for
highly multiplexed bioassays. Our new barcoding approach not only outperforms
existing technologies in terms of multiplexing capability, but has better sensitivity,
specificity and is much more versatile. Specific application to miRNA sensing will be
discussed.
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Date
2011-09-28
Extent
63:30 minutes
Resource Type
Moving Image
Resource Subtype
Lecture